Endometrial hyperplasia is a histological diagnosis. It refers to hormone-dependent diseases, which are treated with various hormonal drugs and surgical methods. At the same time, the method and timing of monitoring of the effectiveness of treatment depend on the initial morphological diagnosis.In recent years, there have been many changes in the classification, diagnosis and treatment of this disease. So, in 2014, a new international classification was developed by the International Agency for Research on Cancer and the World Health Organization, based on the identification of atypical cells in endometrial hyperplasia with modern molecular genetics and immunohistochemical methods. According to this classification, only two categories of endometrial hyperplasia are distinguished: with and without atypia. At the same time, the introduction of this classification in Ukraine is impossible without the involvement of morphologists and the development of a unified diagnostics strategy.The goal of the treatment of endometrial hyperplasia is the relief of symptoms (abnormal uterine bleeding, pain) and the prevention of relapses, and most importantly the timely detection of concomitant invasive endometrial cancer. During the diagnostic search for endometrial hyperplasia at any age, alertness for cancer must be present. Currently, the search for safer methods of timely detection of endometrial cancer early stages has been given great attention, but due to imperfect methods, there are still difficulties in diagnosing and predicting benign and malignant proliferative processes.An unfavorable outcome in the inadequate management of patients with benign tumors and uterine hyperplastic processes, especially when combined, is radical surgical treatment − hysterectomy. And only the mutual work of morphologists and gynecologists, which are aware of the difficulties in diagnosis and treatment, namely the presence of resistance to certain pharmacological groups of drugs in a number of women, will not allowed to lose time and review the strategy of management for that patients for applying the reasonable methods of treatment.

There are certain difficulties in the diagnostics of visceral obesity, but many of them are surmountable in modern conditions. Women with PCOS need the use combined oral contraceptives with both contraceptive and curative purposes. Therefore, the choice of the medicine depending on the clinical situation, the peculiarities of redistribution of adipose tissue is important in clinical practice. With the correct choice of COC, there will be no significant adverse effects on the metabolic profile of patients with PCOS and, possibly, a positive effect on their lipid profile will be observed. And yet, weight loss can lead to spontaneous ovulation in women with PCOS and overweight or obese, so the first choice in treatment of such patients should be diet and lifestyle changes, including an increase of daily physical activity.

The article considers the main points that affect the quality of life of women with varicose veins of small pelvis with congestion and without it, in particular the use of hormonal methods of contraception, and also discussed the issues of diagnostics, prevention and treatment of these diseases. Algorithms of clinical tactics for conducting such patients are presented. Particular attention is focused on the features of the appointment of hormonal drugs in this category of women. You can determine the methods of treatment and avoid long-term unreasonable prescription of various medicine (especially hormones that will mask or worsen the course of the disease) if you select groups of women with varicose veins of the small pelvis without congestion and with it (reflux).Varicose veins of the small pelvis and pelvic congestion syndrome are conditions that require an interdisciplinary and differentiated approach. Symptoms of these conditions can be put on a mask of various gynecological, urological, traumatological diseases. Anatomical and physiological features of the structure of the veins and the regulation of their venous tone explain the possibility of forming a venous congestive syndrome in women. This can be due to two reasons: due to the violation of the outflow of venous blood or due to the obstruction of any vein of the ovary, any increase in intravascular pressure not controlled by the venous tone at the level of the pelvis.Varicose veins of the small pelvis and pelvic congestion syndrome remain unexplored until the end. There are no uniform standards for their diagnostics. Varicose veins of the small pelvis and pelvic congestion syndrome are different diseases which requiring an understanding of the mechanisms of their development and consequences. If a pelvic varicose veins are suspected, the first diagnostic test is usually ultrasound. Modern ultrasound technique can evaluate blood flow in various veins. To study the blood flow in the veins, laparoscopy, venography in combination with CT or MRI can also be performed.

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Current guidelines of acne treatment are not effective in different women. Dissatisfaction with the esthetic results of treatment creates the need to optimize the treatment of late acne in active reproductive aged women.Objective of the study: to evaluate the effectiveness of developed comprehensive method for the treatment of late acne in active reproductive aged women.Materials and methods. 32 patients with acne tarda aged 25–40 years were examined and treated, including women with acne of I degree of severity – 18.8%, II degree – 30.6%, III degree – 46.8%. Biophysical parameters of skin (fat, moisture, elasticity and erythema degree) were determined before treatment, after 3 and 6 months and expressed in arbitrary units. The control group consisted of 8 conditionally healthy women of the corresponding age without acne. Treatment efficacy was evaluated in 3 comparison groups: group 1 – 10 patients who received conventional therapy; group 2 – 12 patients in whom traditional therapy was combined with combined oral contraceptive (COC) Belara, group 3 – 10 patients in whom traditional therapy was combined with COC Belara and Richter CycloBalance.Results. A comparative analysis of the inflammatory dynamics (papules, pustules, nodes, cysts) and non-inflammatory rash elements (open and closed comedones), skin biophysical parameters (fat, porosity, hydration, erythema, elasticity) before treatment, after 3 and 6 months of therapy showed the advantage of combined use COC Belara and Richter CycloBalance in the complex treatment of late acne in active reproductive aged women.Conclusion. Complex therapy of late acne in active reproductive aged women with COC Belar and Richter CycloBalance increases the effectiveness of therapy and aesthetic skin status.