The use of dental implants for the treatment of partial and complete adentia is increasing every year. Following this, despite the improvement in the quality of dental services, the percentage of complications also increases. One of the most common complications in implant treatment is peri-implantitis. The microorganisms causing this process are in the biofilm on the surface of the implant, which complicates the treatment and reduces the effectiveness of antimicrobials. One of the principles of modern medicine is prevention, which opens up new prospects for the use of probiotics.
Titanium has been successfully used in dental implantology for a long time. Due to the osseointegration process, titanium implants are able to withstand the chewing load. This article is devoted to the study of surface treatment methods of titanium alloys and the study of their interaction with mesenchymal stem cells (MSCs). The surface microrelief can influence MSC differentiation in different ways, which subsequently gives it osteogenic potential. The paper proposes modes of surface modification of titanium alloys on Grade 4 and Grade 1 by chemical and electrochemical (anodizing) etching. The possibility of modifying the surface of titanium alloys using the synthesis of graphene layers has been proposed in this paper for the first time. The osteogenic potential of a particular surface was assessed by the number of mesenchymal stem cells cultured on them under identical conditions.
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