Deficiencies of vitamins C, D, and E, copper, selenium, and zinc in patients with burns are related to poor clinical outcomes. The physiology of the deficiencies is likely multifactorial, with tissue catabolism, hormone response, oxidative stress, hypoalbuminemia, wound losses, and medications being contributors. Micronutrient supplementation in patients with burns has theoretical benefits and is administered to adults in intensive care units. However, limited data exist for children with burns. This review focuses on evidence of micronutrient deficiencies and increased micronutrient requirements in pediatric patients with burns, discusses intervention studies and supplementation guidelines for pediatric and adult patients, and explores the gaps in current research.