In comparative aspect the clinical efficiency of natural estrogen - 17 - - estradiol and phytoestrogens for elimination of climacteric syndrome and age hyperlipoidemia appearing was studied. Climadinon can be considered as alternative classic substitute therapy preparation for the treatment of vasovegetal disorders within climacteric syndrome. The absence of side effects allows recommend this preparation on the first stage of patients treatment. Should the phytoestrogens effect became weaker, on the second hormonotherapy stage it is possible to obtain the disorders compensation by means of prescribing preparations, containing natural estrogens.