Natural killer (NK) cells are capable of lysing their target cells with the help of perforin. The application of these cells for immunotherapy requires the estimation of their potency for the purpose of validation and batch-to-batch comparison. Cytotoxicity measurements have been carried out at only a few effector target ratios, therefore, allowing only semiquantitative assessment at best. By using a novel approach of varying the effector target ratio continuously and careful analysis of the experimental data after the reactions, we have achieved a precision necessary for constructing a mathematical model of cytotoxic reaction. Curve-fitting to experimental data indicates that NK cell cytotoxicity follows the law of mass action and fits the model of a single ligand-receptor interaction. The method allows to use the value of half-maximal lysis to describe the potency of cytotoxic NK cells numerically. ' 2013 International Society for Advancement of Cytometry

Introduction. The article actualizes the problem of monitoring the qualitative indicators of higher education in modern Russian universities. The opportunities for monitoring to identify the levels of university graduates’ satisfaction with the obtained education considering the rapidly changing socio-cultural and economic conditions are disclosed. Goal: substantiation of heuristic possibilities for monitoring the quality of higher education in accordance with the social demand. Methods. At the basis of the study methodology lies the systemic approach allowing the authors to conduct a comprehensive analysis of the specific features of monitoring. The analysis, generalization, and classification of the main indicators constituting the foundation for the study of university graduates’ satisfaction with the quality of education are conducted. Results. The article presents the results of monitoring studies and proposes a classification of methodological and methodical approaches to the study of the topic. Scientific novelty. The topic of monitoring university graduates’ satisfaction with the quality of education allows the authors to explore the main relevant problems of modern universities and disclose the potential of higher education. Practical significance. The acquired study results can be used in further research, scientific and methodical developments, and project activity aimed at improving students’ satisfaction with the educational process and promote the quality of pedagogical work.

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El propósito del artículo es determinar la satisfacción de los graduados universitarios con la calidad de la formación en los programas educativos. La metodología de investigación se basa en las características de la calidad de la educación, que pueden expresarse en determinados indicadores cuantitativos. Tales características medibles incluyen evaluaciones cuantitativas tradicionales del nivel de conocimiento adquirido, indicadores cuantitativos de la demanda de especialistas graduados en el mercado laboral y el grado de satisfacción con la formación de los propios estudiantes. El estudio incluyó a 120 egresados del grupo ampliado de “Estudios culturales y diseño sociocultural” de los años 2018-2020. Se utilizaron los siguientes métodos: métodos de encuesta: cuantitativos (cuestionario) y cualitativos (entrevistas). La metodología propuesta y probada para medir la satisfacción de los egresados universitarios con los programas educativos puede convertirse en la base para el desarrollo de un sistema universitario de seguimiento de la medición de la satisfacción de los egresados universitarios con los programas educativos y un sistema de gestión de la calidad universitaria.

The article considers innovative approaches to the study of social interaction on the basis of the use of techniques of the musical forms analysis. As the baseline for revealing these approaches the pedagogical process in teaching music disciplines is elucidated. The authors reveal some algorithms of such analysis opening up new perspectives not only in music pedagogics but also in the study of cultural processes: their structure, internal logic, and dynamics of development. The analysis, demonstrated in the article, represents essentially new ground for researches for music pedagogics, cultural science and social anthropology delimited from the minor impacts and factors in the study of cultural processes.