Safflower production is actual in climatic conditions of the Western Kazakhstan, which is characterized with high heat supply and long vegetative period. In recent years, safflower crops in the Western Kazakhstan region did not exceed 29,000 ha and seed yield was quite low – 0.3–0.5 t per ha. Studying of biologized technologies of safflower cultivation is very important for crop productivity increase and sowing areas expanse. Next to the introduction of the highly productive varieties, perfection of agricultural techniques, especially application of biologic preparations, is a significant reserve of safflower yield increase in a system of organic farming. The purpose of the research was to study and estimate biologized technology of safflower cultivation in the Western Kazakhstan to supply producers with qualitative oil materials in a system of diversified plant growing. The researches were conducted in 2019–2020; we studied features of crop growth, development, productivity and seed quality when cultivating safflower with biologized technology in conditions of the first dry steppe zone of the Western Kazakhstan region. Due to results of comparative studying, seed yield and oil content in seeds of safflower were higher: 0.764 t per ha and 30.0%, respectively, when using biologized technology. The highest oil yield (0.229 t per ha) was received at joint application of a biopreparation Biodux, a biofungicide Orgamica S and a biofertilizers Organit N, Organit P (biologized technology) for seed disinfection and plants treatment during safflower vegetation, that was by 0.057 t per ha, or by 33.1%, higher than at traditional cultivation technology.