Objective. To determine clinical efficacy of the preparation «Aсtovegin», included in the complex therapy of patients with CHD. Material and methods. The research included patients aged from 30 to 60 with ischemic heart disease, i.e. stable stenocardia of I-III functional classes (chronic heart insufficiency of I-III functional classes according to NYHA classification and/or portinfarction cardiosclerosis). The average age at the moment of the examination was 55,03 ± 0,53. A total of 243 patients were examined, and of them, 216 patients were treated with aсtovegin. The statistic data were processed with the use of the standard set of statistic programs «Statistica», 6,0 (StatSoft, USA). Results. An earlier stabilization of stenocardia and relatively greater level of readaptation to physical activities as well as decrease of ejection fraction (EF) were observed in the patients treated with actovegin. The analysis of the biochemical blood values revealed that the treatment with this preparation led to a significant decrease in cholesterol, low- and very low-density lipoproteids. Conclusion. Actovegin in the complex therapy of patients with CHD stimulates contractile ability of cardiac muscle, has a positive effect on cardiac pumping function. Possessing an antihypoxic, insulin-like, cytoprotective and reperative effects, it corrects tissue metabolism, at the same time improving the biochemical blood values in the patients with CHD.

Objective: to study the possibility of diagnosis of spinal static deformities using the method of topographic photometry over time before and after rehabilitation follow-up in school-aged children. Material and methods. The study involved 411 children (207 boys and 204 girls) aged 6-16. 77 children with spinal deformities (scoliosis, postural disorder) underwent complex rehabilitation treatment. 46 patients were done X-ray investigation. Results. The groups of the boys and girls were analyzed in accordance with the data of their examination by the method of topographic photometry. The data of topographic photometry obtained after the examination of the children before the treatment and 6 months after it were analyzed. The X-ray and topographic data were compared. The results of X-ray and optical topography were identical in 35 (76 %) cases. Thus, the method of topographic photometry makes it possible to estimate the results of rehabilitation activities in children without extra X-ray exposure. Conclusion. The high information value of topographic photometry without radiation exposure defines the reasonability of the use of this method for the control of efficiency of rehabilitation activities in static spinal deformities in children.

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Objective: to determine the type of changes of shear stress in vessels of the vertebrobasilar system in patients of young age with spondylogenic vertebrobasilar insufficiency (SVI). Material and methods. We examined 131 patients (70 women and 61 men) aged 18-40 (average age was 29.8 ± 3.8) with manifestations of spondylogenic vertebrobasilar insufficiency associated with muscular reflex, neurovascular and radicular syndromes of osteochondrosis of the cervical part of the vertebral column. 25 healthy donors made the control group. All the patients underwent radiological examination of the cervical part of the vertebral column with functional probes, doppler and duplex ultrasound of vessels of the neck and arteries of the head with functional probes; we performed the detection of endothelin-1, nitric oxide (NO) of blood serum. The changes of the shear stress in vessels of the vertebrobasilar system were assessed analyzing the Stuart index (ISD), systolic and diastolic parameter. Results. It has been found that development of spondylogenic vertebrobasilar insufficiency is accompanied by signs of endothelial dysfunction (ED), which is characterized by increased concentration of endothelin-1 related to the reduction of active metabolite of nitrogen oxide - S-NO. One of the mechanisms of ED in this cohort of patients is changes of the shear stress. Conclusion. In order to predict the development of ED in patients with spondylogenic vertebrobasilar insufficiency, it is recommended to pay particular attention to the state of the vascular wall.

Гомельский государственный медицинский университет,Институт радиобиологии НАН Беларуси, г. ГомельПрименение атомно-силовой микроскопии (АСМ) для исследования микро-и наномасштабных участков поверхности клеток позволяет ввести новые клеточные параметры, получить качественно новые представления о причинах и механизмах изменения свойств клеток. Целью работы являлась оценка на примере клеток крови состояния и перспектив АСМ для изучения и разработки новых методов диагностики заболеваний на основе анализа специфики режимов работы АСМ и новых АСМ-данных о свойствах поверхности клеток.Ключевые слова: атомно-силовая микроскопия, цитоскелет, модуль Юнга, механические свойства клеток, фрактальная размерность, эритроциты, лейкоциты, раковые клетки, патология.