Anaplastic thyroid cancer is one of the most aggressive and fatal human carcinomas. A significant experience in using various kinase inhibitors for anaplastic thyroid cancer therapy has been accumulated worldwide. The most encouraging results were obtained after using a combination of b-Raf and MEK kinase inhibitors (vemurafenib/dabrafenib and trametinib/cobimetinib, respectively) for the treatment of the unresectable BRAFV600E-positive anaplastic thyroid cancer. This drug combination makes it possible to perform surgery followed by chemoradiotherapy and other targeted therapies. Here we report a clinical case of anaplastic thyroid cancer in a 69-year-old woman, who was treated with neoadjuvant targeted therapy. The treatment was carried out on the basis of three medical institutions: the National Medical Research Radiological Centre (Moscow), the N.I. Pirogov Clinic of Advanced Medical Technologies (St. Petersburg) and the Endocrinology Research Center (Moscow). Since there is still no universal protocol for treating ATC patients, and only palliative therapy is used in most cases, we emphasized on diagnostic and treatment errors of this disease. Special attention was paid to the importance of using molecular diagnostics and modern medical imaging technologies.

Differentiated thyroid cancer

Aim. To develop and improve new ways of surgical treatment for deep burn injuries and their consequences with use of vacuum therapy and cell technologies.Material and methods. In the present article clinical examples of vacuum therapy application for two groups of patients are given. In the first group there were patients with total deep burn injuries of the body, the second group included patients with multiple scarry deformations of hands. In both groups during surgical treatment patients underwent autodermoplasty of wound defects with the subsequent imposing of vacuum dressings, in the first group the cell cultures of the frozen dermal allofibroblasts were also used.Results. We achieved sufficient clinical outcomes in both groups.Conclusion. Vacuum therapy creates optimal conditions for engraftment of autodermotransplantats and reduces terms of wound preparation for autoplasty.

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