Relevance. Morpho-functional changes in peripheral circulation established in type 1 diabetes mellitus correlate with changes in central hemodynamics, allowing the use of microcirculation indicators as diagnostic and prognostic criteria for assessing the degree of functional vascular disorders. Identifcation of microcirculation features of the blood by the method of laser Doppler flowmetry in children with different experience of type 1 diabetes in key age categories.Materials and methods. The study included 67 children with type 1 diabetes mellitus aged 12-15 years with an experience of the disease from six months to ten years. The comparison group consisted of 38 healthy children. The state of the microvasculature was assessed by laser Doppler flowmetry using a laser analyzer for capillary blood flow LAKK-OP.Results. In children with an experience of type 1 diabetes of less than two years, microcirculation disorders in periodontal tissues correspond to the hyperemic form, accompanied by increased perfusion, a decrease in the amplitude of low-frequency oscillations, increased heart rate, high blood flling, and blood flow bypass. For children with an endocrinopathy experience of more than three years, microcirculation disorders correspond to a stagnant form, combined with a decrease in perfusion due to stagnation of blood in the venular link, endothelial domination with suppression of neurogenic and cardiac fluctuations, low efciency and redistribution of blood flow in favor of the nutritive link.Conclusions. With the increase in experience, the degree of compensation of type 1 diabetes, the progression of diabetic microangiopathy, it is advisable to designate two stages of development of microcirculatory disorders. Early – compensatory with active adaptation, including neurogenic and endothelial regulation mechanisms. Late – decompensation with passive adaptation, supporting the effectiveness of microcirculation due to myogenic control of regulation, shunting and increasing the rate of blood outflow.

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Relevance. Detection of maxillofacial pathomorphological changes in children with connective tissue dysplasia (CTD) allows identifying the nature and severity of disorders, as well as it serves the basis for selecting the best treatment options in view of the pathogenetic features. The purpose is to improve the diagnosis of periodontal diseases in children with CTD based on x-ray morphometric indices of the lower jaw and peripheral skeleton ultrasound osteodensitometry.Materials and methods. 92 children with varying CTD severity, and 43 healthy children, underwent cone-beam computed tomogram examination with a further analysis of their X-ray morphometric (quantitative, qualitative) values and the lower jaw optical density indices. Besides, the status of the peripheral skeleton bone tissue was also determined through quantitative ultrasonic densitometry.Results. Quantitative X-ray morphometric indices in healthy children and children with CTD revealed strong positive correlation with the Z-criterion of osteodensitometry, offering an objective reflection of the bone tissue status in the peripheral skeleton.Conclusion. CTD progression in children correlates with the bone structure destruction intensity in the maxillofacial area, an increase in chronic productive inflammation, a decrease in the bone density, bone tissue fibrous transformation, a decrease in the thickness of cortical, and fiber-dissociation in closing, plates, of the lower jaw, prevalence of mid- and fine-meshed bone pattern, disturbed spatial orientation and thinning of bone trabeculae, as well as the development of pathologies in the periodontium.

Relevance. The high prevalence of microvascular complications in children with type I diabetes mellitus (DM) has a serious impact on the quality of life and can result in a lower working capacity and early disability. The negative effect of the drug therapy, inability to fully comply with the acceptable age-related safety limits, specific metabolism and pharmacokinetic features in childhood – all these reveals the need to improve the patterns for comprehensive treatment of periodontal diseases in children with type I diabetes.The purpose was to explain the clinical and functional effectiveness of the combined enzyme and magnet & laser therapy in comprehensive treatment of the periodontal microcirculatory disorders in children suffering from type I diabetes. Materials and methods. The study involved 97 children diagnosed with type I diabetes, aged 12-17 y.o., with the present disease history from 6 months to 12 years. The microcirculation was assessed by laser Doppler flowmetry. Microcirculatory disorder correction was performed by a local exposure to a running low-frequency pulsed magnetic field combined with enzyme therapy. Results. The dynamic magnetic therapy has proven to increase the effectiveness of capillary blood flow in children with early signs of vascular congestion and hyperemia, while Phlogenzym, a polyenzyme formulation, needs to be added in cases of vascular congestion and ischemia. Conclusion. The effectiveness of physiotherapeutic and pharmacological effect of Phlogenzym along with the dynamic magnetic therapy shows that it can be recommended as an alternative to the conventional anti-inflammatory, antiseptic and antibiotic therapy during the pre-surgical treatment and post-surgical follow-up care as well as at the maintenance phase, both in an inpatient and outpatient setting.

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