The article discusses the modern principles of lipid-lowering therapy and approaches to its administration in terms of levels of cardiovascular risk. The characteristics of groups of patients with different levels of cardiovascular risk (from low to high) in primary prevention are given. The article defines the target levels of low- density lipoprotein cholesterol, which should be achieved with the modern lipid-lowering therapy. The clinical effects of statins in primary prevention are presented. The clinical results of two large studies of rosuvastatin that have changed the approach to statin prescribing in primary prevention are discussed. The article presents the results of the analysis of long-term follow-up of patients in the primary prevention after the completion of randomized clinical studies. Approaches to the use of statins for novel coronavirus infection are considered.

Purpose of the study. Evaluate the clinical efficacy of early poststationary rehabilitation of persons with coronary heart disease (CHD) who underwent coronary artery bypass grafting (CABG) in a cardiac rehabilitation outpatient department (III stage cardiorehabilitation). Material and methods. The study included men (n=36) suffering from coronary artery disease and had undergone CABG after 3-8 weeks after surgery (an average of 7.8±1.6 weeks). Patients were randomized into two groups: the main group where patients are involved in the educational program "School for patients undergoing CABG" (hereinafter - the "School"), controlled and uncontrolled (at home) physical training (PT) - the control group, where patients were only training in the educational "School" with a recommendation to participate in an uncontrolled PT under the house. Classes in education "School" held 1 time per week, lasting 60-80 minutes, for 5 weeks; controlled PT - 3 times per week for up to 60 minutes in the groups for 4 months. The total duration of the observation - 1 year. Patients underwent instrumental tests - electrocardiogram rest, echocardiography, bicycle stress test, laboratory tests of blood - lipid and lipoprotein, glucose, fibrinogen, a survey by questionnaire of motor activity, nutrition, quality of life, HADS (Hospital Anxiety and Depression Scale). Results. After a 4-month course of the PT there was a significant indicator of physical performance. The duration of exercise at the end of the course PT increased from baseline by 32.6% (p

Aim.To provide modern view on atherogenic disorders in the blood lipid spectrum, the principles of lipid-lowering therapy prescription in certain groups of patients, the safety issues of statin therapy in patients with chronic liver diseases. Materials and methods.The data of 55 scientific sources published in the Russian and foreign press in 19882020 were analyzed. Results.It is known that atherogenic dyslipidemia is a key factor in pathogenesis of atherosclerotic cardiovascular diseases. Various disorders in blood lipids and lipoproteins are identified. In this regard, there are certain recommendations for the analysis of lipids and lipoproteins in certain situations. The issues of interpreting extreme deviations from normal values of the blood lipid spectrum are discussed. Patient groups with different levels of the cardiovascular risk, which determines prescription of lipid-lowering therapy, are presented. Statins are the first line of lipid-lowering therapy for both the correction of dyslipidemia and the prevention of cardiovascular complications. The article discusses the tactics of prescribing statins in special groups of patients, their safety issues. It considers promising ways for increasing statins tolerability in patients with chronic liver diseases, primarily with non-alcoholic fatty liver disease, by adding of combined hepatoprotector. Conclusions.Generally, modern tactics of statins prescription are based on dyslipidemia characteristics and the patients cardiovascular risk level. Moreover, statins are clinically effective in special patient groups and have a good tolerability profile.

The purpose of this article is to discuss the issues related to the treatment of patients with paroxysmal and persistent atrial fibrillation (AF). The article discusses the indications for patients with radiofrequency catheter (RFC) ablation of the mouths of the pulmonary veins and based on the results of randomized clinical trials analyzed the clinical effects of this procedure, depending on the type of AF. The article discusses the initiation of antiarrhythmic therapy and the duration of its application after RFC.

The article is devoted to the problem of organizing cardio rehabilitation in the Russian Federation. The results of clinical studies and meta-analyzes assessing the clinical effectiveness of cardiac rehabilitation are presented. The advantages of cardiac rehabilitation, both clinical and economic, are indicated. The problems of slow pace of organization of the cardio rehabilitation infrastructure in the country are analyzed.