Purpose. Against the background of new coronavirus disease COVID-19 and increasing cases of infection of the personnel of naval ships and vessels of NATO countries, leadership of great maritime powers has to initiate the correction of naval policy and its adaptation to contemporary conditions, seeks an increasing sustainability of naval structures to future epidemic risks and intends to minimize the effects of quarantine restrictions.Materials and methods. Aspects of work of commanding officers and captains of vessels (officials) aimed at prevention of introducing and spread of actual infection at two stages of epidemic prevention measures were examined: 1) in the pre-voyage preparation period; 2) when performing sea duties, in the case of appearance of a crew member suspicious for infection with a novel coronavirus disease COVID-19 on board ship.Results and discussion. The experience of the Russian Navy in the implementation of organizational, educational, epidemic prevention and control measures was presented. It allowed to confine the actual disease on ships.