Aim. To study scientific literature which covers the onset and course of major periodontal diseases and possible methods of body modulation for such patients. To analyze the information provided by the modern scientific researches of periodontal diseases pathogenesis and treatment results to outline prospective directions of therapeutic influence on the patient’s organism.
Conclusions. The pathogenesis of gingivitis and periodontitis is determined by some factors, the main of which are local, microorganisms in particular, that are counteracted by the immune system. Periodontal tissue is in close contact with the organs and systems of the body. Their diseases significantly affect the course, treatment and prevention of periodontitis. This requires a multifaceted approach and the choice of the most effective drugs.
The primary strategy of preventing gingivitis is to eliminate the attachment of periodontal pathogens to the epithelium and surface of the teeth to prevent the penetration of microorganisms and their toxins through natural protective barriers. It is more important to resort to biological approaches using probiotics, as well as other natural media in order to prevent dysbiosis, long-term treatment, and maintenance therapy. The concept of vaccination against periodontitis is now being elaborated. Correction of the pathological process in the periodontium is considered in the context of the overall biological response of the organism. Therefore, the assessment of the role of its regulators reveals not only the features of local mechanisms, modulation pathways, but also the choice of effective drugs. Prospects of new approaches and introduction of highly effective drugs are critically analyzed.
Львівський національний медичний університет ім. Данила Галицького Державна установа «Інститут стоматології та щелепно-лицевої хірургії Національної академії медичних наук України» ВПЛИВ ВИСОКОЖИРОВОГО ХАРЧУВАННЯ НА СТАН ЯСЕН ЩУРІВ Мета. Визначити вплив харчових жирів з різним жирнокислотним складом на стан ясен щурів.
Keywords: liver, phospholipids, essential fatty acids, palm oil, dysbiosis, herbal medicine. Aim. To study the effect of the phytopreparation kvertulin on the processes of biosynthesis of PUFA of liver phospholipids in rats treated with palm oil against the background of dysbiosis. Methods. Rats consumed a fat-free diet (group 1), a diet with 15 % palm oil (group 2), a diet with 15 % palm oil on the background of experimental dysbiosis (group 3) and a diet with 15 % palm oil on background of dysbiosis + kvertulin. The duration of the experiment is 40 days. The content of fatty acids in liver phospholipids was determined by gas chromatography. The ratio of the PUFA content was used to calculate the “activity” of ω-3-desaturase, the intensity of synthesis of arachidonic acid, and the intensity of synthesis of docosahexaenoic acid. Results: In rats of the 3rd group, which received palm oil against the background of dysbiosis, there was a decrease in the content of ω-3 PUFA, an increase in the ratio of ω-6 / ω-3 PUFA, and a decrease in the “activity” of ω-3-desaturase. In rats of the 4th group, which received kvertulin, the content of PUFA was completely restored and the “activity” of enzymes of their biosynthesis was normalized. Conclusion. The use of the phytopreparation kvertulin normalizes the endogenous biosynthesis of PUFA of liver phospholipids in rats consuming palm oil against the background of dysbiosis.
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