Aim. To study scientific literature which covers the onset and course of major periodontal diseases and possible methods of body modulation for such patients. To analyze the information provided by the modern scientific researches of periodontal diseases pathogenesis and treatment results to outline prospective directions of therapeutic influence on the patient’s organism. Conclusions. The pathogenesis of gingivitis and periodontitis is determined by some factors, the main of which are local, microorganisms in particular, that are counteracted by the immune system. Periodontal tissue is in close contact with the organs and systems of the body. Their diseases significantly affect the course, treatment and prevention of periodontitis. This requires a multifaceted approach and the choice of the most effective drugs. The primary strategy of preventing gingivitis is to eliminate the attachment of periodontal pathogens to the epithelium and surface of the teeth to prevent the penetration of microorganisms and their toxins through natural protective barriers. It is more important to resort to biological approaches using probiotics, as well as other natural media in order to prevent dysbiosis, long-term treatment, and maintenance therapy. The concept of vaccination against periodontitis is now being elaborated. Correction of the pathological process in the periodontium is considered in the context of the overall biological response of the organism. Therefore, the assessment of the role of its regulators reveals not only the features of local mechanisms, modulation pathways, but also the choice of effective drugs. Prospects of new approaches and introduction of highly effective drugs are critically analyzed.

Resume. The most common and universal method of treating periodontitis is periodontal pocket curettage and root surface smoothing (SRP), after which it is important to prevent re-infection of the pocket. For this purpose, antibiotics and other antimicrobial drugs are prescribed. For many years, periodontists have used the systemic administration of high doses of antibiotics during and after the completion of SRP in order to achieve the desired concentration of the drug in the gingival fluid. Such tactics often led to organic complications. In recent years, the method of introducing antimicrobial agents immobilized on natural or synthetic polymers directly into the periodontal pocket has become widespread. Such compositions slowly dissolve on the spot and eventually release the desired drug component. The study analyzes the publications of recent years on the use of controlled release systems of drugs injected into the periodontal pocket. The most common problems that may arise during the application of this method of treatment are analyzed. The advantages and disadvantages of using such systems are indicated. The indications and contraindications for the use of controlled drug delivery systems are considered, data on their comparative clinical efficacy are given. The main dosage forms used for introduction into the periodontal pocket are described, the drugs registered and sold in Ukraine are listed and the data on their therapeutic efficacy. The future prospects of application of this method in periodontology are also considered in the work. Key words: periodontitis treatment, controlled local drug delivery systems, dental gels and films.