The necessity of estimating the decrease in the accuracy of measuring the informative parameters of a radar signal in real conditions of its propagation and reflection has been substantiated. The results of the estimation determine the requirements for optimizing this measurement to achieve the required efficiency. A numerical analysis of the decrease in the accuracy of measuring the Doppler frequency of a coherent packet is presented, depending on the statistical characteristics of fluctuations of the initial phases of its radio pulses. Expressions are given for calculating the fluctuation component of the measurement error of radio pulse packet frequency for various coefficients of interpulse correlation of phase fluctuations. An assessment is made of the possibility of increasing the accuracy of Doppler frequency measurement, which can be ensured by statistical optimization of the algorithm for time-frequency processing of a given radar signal by taking into account its phase fluctuations. The conditions for the multiplicative influence of phase fluctuations of radio pulses of the received packet are substantiated, which determine the efficiency of optimization of Doppler frequency measurement. Based on the results of the study, an optimization method for measuring the Doppler frequency of the packet taking into account fluctuations in the initial phases of its radio pulses is proposed. The accuracy of Doppler frequency measurement under the influence of both the internal noise of the radar receiver and the correlated phase fluctuations of its radio pulses is estimated. The efficiency of optimization of measuring the Doppler frequency of the packet is estimated taking into account fluctuations of the initial phases of its radio pulses by means of computer simulation. It is proved that, under the influence of phase fluctuations, the accuracy of Doppler frequency measurement can be increased due to the performed optimization from 1.86 to 6.29 times. This opens the way to improving the existing algorithms for measuring the higher time range derivatives to improve the quality of tracking complex maneuvering aerodynamic objects. This explains the importance and usefulness of the work for the radar theory.

Benign prostatic hyperplasia (BPH) — one of the most common urological diseases that lead to the development of symptoms of the lower urinary tract (SLUT). BPH-multifactorial disease, in which a significant role is given to increase the activity of the enzyme 5a-reductase and hormonal imbalance associated with the exchange of testosterone and dihydrotestosterone. However, to date, not all aspects of the etiology and pathogenesis of this condition have been studied. The results of numerous studies indicate a significant role of complex metabolic disorders included in the modern concept of "metabolic syndrome" (MS), the development and progression of BPH/SLUT. The main pathogenetic factors leading to the formation of BPH and concomitant urination disorders are considered to be a violation of the balance of sex hormones, the development of chronic ischemia of the pelvic organs, a violation of carbohydrate and lipid metabolism. The relationship between BPH and MS is one of the most urgent problems of modern medicine. Different components of MS independently from each other can influence more pronounced progression of BPH/SLUT in comparison with development of this disease in men without metabolic disorders that is the reason of lower efficiency of surgical and medical treatment of this group of patients.

Purpose of the study. To improve the results of treatment of benign prostatic hyperplasia with symptoms of the lower urinary tract in the presence of concomitant metabolic syndrome.Materials and methods. The investigation included 103 patients aged 42 to 75 years with a reliable diagnosis of BPH and signs of MS, according to the criteria of GFCF (2009). Patients were randomized into two comparable groups: Group 1 included 52 men who were prescribed tamsulosin in combination with targeted correction of metabolic disorders; Group 2 consisted of 51 men who were prescribed tamsulosin monotherapy. After 6 and 12 months of the study, the dynamics of metabolic parameters, prostate volume, residual urine volume, maximum urine flow rate, and total IPSS and QoL score were evaluated in each group of patients.Results. A direct correlation was established between the severity of metabolic disorders and the progression of BPH /LUTS in the main assessed indicators. The use of combination therapy with metformin, ACE inhibitors / ARA and statins in combination with tamsulosin showed efficacy after 6 and 12 months of the study compared with tamsulosin monotherapy. The treatment is based on the rinciple of T2T ("Treat to Target"): maintaining target levels of blood pressure, glucose, blood lipid parameters, and body weight correction.Conclusion. Overweight, arterial hypertension, the atherogenic profile of dyslipidemia and hyperglycemia are risk factors for more pronounced progression of BPH / LUTS and a deterioration in the quality of life of patients. The investigation IMSYPA showed the effectiveness of pathogenetically based complex therapy aimed at eliminating metabolic imbalance.

Информация о финансировании. Финансирование данной работы не проводилось. Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.

Рязанский государственный медицинский университет имени академика И.П. Павлова, Рязань, Российская Федерация _____________________________________________________________________________ Доброкачественная гиперплазия предстательной железы (ДГПЖ) -распространённое возраст-зависимое урологическое заболевание, имеющее важное медико-социальное значение и являющееся, по мнению многих авторов, ведущей причиной симптомов нижних мочевых путей у мужчин (СНМП). По современным представлениям, ДГПЖ -это мультифакторное заболевание, в развитии и прогрессировании которого определённая роль отводится каскаду метаболически взаимосвязанных нарушений углеводного и липидного обменов, ассоциированного с висцеральным ожирением и артериальной гипертензией, объединённых в понятие «Метаболический синдром» (МС). В связи с выявленным негативным влиянием МС на ДГПЖ, с целью достижения необходимого эффекта в лечении СНМП и уменьшении объема аденомы предстательной железы, а также улучшения качества жизни пациента, необходимо своевременно и грамотно корректировать каждый компонент МС. В статье представлено клиническое наблюдение, демонстрирующее эффективность комплексной консервативной терапии у пациента с ДГПЖ/СНМП и сопутствующим МС. На фоне строгой диеты, физических упражнений, снижения массы тела, нормализации уровня артериального давления, показателей липидного спектра, коррекции углеводного обмена в сочетании с назначением тамсулозина у пациента с ДГПЖ/СНМП достигнуто уменьшение размеров предстательной железы, снижение выраженности СНМП и значительное улучшение качества его жизни. В основу тактики ведения пациентов с данной коморбидной патологией положен принцип «Treat to Target» -лечение до достижения цели. Ключевые слова: доброкачественная гиперплазия предстательной железы; симптомы нижних мочевых путей; метаболический синдром; коморбидность; ожирение; инсулинорезистентность; гипергликемия; дислипидемия; артериальная гипертензия; лечение до достижения цели.