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This study is aimed at the development of a method to fabricate porous spherical hydroxyapatite (HA)-fluorapatite (FA) granules. The method to produce porous granules is based on liquid immiscibility effect. A suspension of HA -FA powder mixtures in aqueous solution of gelatin and oil as a dispersion media were used. By stirring the mixtures of these immiscible liquids, granules of 50 -200 mm diameter can easily be produced. The granules were characterized with respect to their microstructure, phase composition and specific area. In vitro testing of human plasma protein adsorption onto the granules of HA and fluorhydroxyapatite were performed. No kind of difference in the dynamic protein adsorption between pure HA and the HA up to 10 wt% FA materials has been revealed. q

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Fluorinated hydroxyapatite is known to be less soluble by body fluids, resulting in enhanced resistance to biodegradation in vivo conditions, as compared to the pure hydroxyapatite ceramics. The present work was aimed at the investigation of the effect of minor additions of ultrafine fluorapatite (up to 10 wt%) on the sintering behavior and mechanical properties of hydroxyapatite ceramics. In vitro testing for the osteoblast-like cells viability and proliferation was performed with the samples of varying fluorapatite content. It was found that the fluorapatite addition hinders the sintering shrinkage and lowers the strength, but does not generally affect negatively the viability of the cells.

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