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The paper contains data regarding current state of research and author opinion on realization of diagnostics and therapy improvement in case of infectious hepatitis in dogs based on the form of the disease. A study of worldwide practice and a summary of personal experience of the aspects of clinical manifestation, diagnostics and treatment methods for canine hepatitis have been performed. According to our research canine infectious hepatitis in Sumy region is usually found in dogs at 1-3 (44%) years of age, less of ten at 5-8 (28%) years. The quantity of cases at 3-8 y.o. is 17% and in animals younger than  1 year – 11%. After being introduced into the body, the virus replicates in the regional lymph nodes then appears in the blood (viremia), after 2-3 days it forms masses of core inclusions (Rubart’s bodies) – big, round, acidophilic masses in capillary and vein endothelium in all the organs, especially liver and spleen. As a result liver dystrophy occurs and general body intoxication follows. Further development of the process results in renal and myocardial dystrophy,appearance of multiple blood effusions on mucous and serous membranes. After the neural centers of the brain and spine are being affected the locomotion disorders are observed.At the stage of acute clinical signs the virus is present in blood and all the exudates, while being observed only in kidneys and urine later. The incubation period of spontaneous hepatitis lasts about 6 to 9 days. Currently there are some cases of an acute and peracute course but chronic and latent courses are prevalent. The organ lesions depend on the severity and course of the disease. Infectious hepatitis is being diagnosed based on epizootological, clinical, pathological and laboratory study data as well as virological research and biological test. Use of a treatment regimen including polyvalent serum, anfluron, cobactan, difeniramine, metoclopramide, furosemide, hepavikel, and crystalline IV solutions allowed shorteningofthe treatment period in comparison to average.

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An epizootiology of infectious diseases/conditions of dog in some veterinary clinics from Benue, Plateau states and the Federal Capital Territory in Nigeria were assessed from 2015 to 2018. This study revealed about seventeen (17) infectious clinical cases/conditions from 1865 cases recorded within the period of four (4) years. These comprised of helminthoses (17.8%) having the highest prevalence followed by babesiosis (17.5%), parvovirosis (15.9%), ectoparasitism (11.3%), scepticemia (6.9%), Mange (5.7%), urinary tract infections (4.7%), canine distemper (4.2%), colitis (3.9%), myiasis (2.7%), trypanosomosis (2.1%), leptospirosis and transmissible venereal tumor (1.9%), respiratory infections (1.7%), otitis (1.0%) and orchitis (0.7%). Puppies (0–6 months old) 50.2% were mostly affected. Incidences of diseases were more in Alsatians (23.7%), Cross (22.9%), Nigerian indigenous breed (20.5%), Caucasian (9.6%) and Rottweiler (8.9%). More cases of vaccinated (68.7%) were recorded against the unvaccinated (31.3%) dogs while male (57.1%) dogs had a higher frequency of cases as compared with their female (42.9%) counterpart. Disease incidence was highest in dry season (54.3%) especially in the months of December (13.3%), January (11.1%) and February (10.6%).The highest frequency of disease incidence was recorded in 2015 (36.4%). Most the infectious clinical cases/conditions recorded from this study were preventable cases demanding veterinary care in order to prevent the risk of zoonosis.

Canine yersiniosis is currently a scantily researched disease. Two agents predominately cause yersiniosis: Y. enterocolitica (gut yersiniosis), Y. preudotuberculosis (yersiniosis). There are three clinical forms of the disease: intestinal, generalized and secondary-focal. Current available research states the prevalence of Y. enterocolitica against other biovariants in canine infections. The majority of infected dogs demonstrate both asymptomatic clinical course and unspecific symptoms or serve as a carrier. Meanwhile yersiniosis pose a threat to human health causing a severe complex of symptoms. In some cases the disease can be lethal, thus the disease has both epizootological and epidemiological value. The goal of this paper was to generalize clinical signs in dogs that demonstrated positive reaction to Y. enterocolitica antigen 0:9, which is a dominant causative agent of yersiniosis in the northeastern region of Ukraine. The study was conducted based on clinical data, biochemical and hematological laboratory studies. Contamination of canine subjects with Y. enterocolitica 0:9 was conducted using agglutination reaction using respective antigen. The research showed, that the dominant symptoms in canines, affected by Yersinia serovariant 0:9 were gastrointestinal lesions in 100 % of the cases. The clinical signs included melena or bloody stool, general depression, anorexia, cachexia, more rarely – vomiting, tachypnea and breathing irregularities. The results of biochemical blood assays and CBC were heterogeneous and cannot be used as a specific marker of Yersinia infection. The main method of confirmation for Yersinia infection would be a serological agglutination reaction, which can identify positive diagnostic titers in animal blood samples. Further research is planned to study mono- and concurrent course of Yersiniosis with different infectious diseases.