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Проблемы особо опасных инфекций. 2019; 1 ОБЗОРЫ 98 сибирская язва продолжает оставаться актуальной проблемой здравоохранения в мире, странах снг и российской Федерации [1][2][3][4][5][6].Сибирская язва в Российской Федерации. в 2018 г. сибирская язва зарегистрирована в двух субъ-ектах россии -республиках дагестан и тыва. в апреле в республике дагестан зафиксирован один случай заболевания сибирской язвой. инфицирование жительницы пос. временный (с. гимры унцукульского района) произошло при Ситуация По СибирСкой яЗве в 2018 г., ПрогноЗ на 2019 г.1 ФКУЗ «Ставропольский научно-исследовательский противочумный институт», Ставрополь, Российская Федерация; 2 Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека, Москва, Российская Федерация в обзоре проведен анализ заболеваемости сибирской язвой в российской Федерации за период с 2009 по 2018 год, показавший, что инфекция среди людей регистрировались в 14 субъектах шести федеральных округов. выявлено 23 вспышки сибирской язвы среди людей, в процессе которых заболело 90 человек с тремя летальными исходами. в сравнении с предыдущим десятилетним периодом (1999-2008 гг.) число случаев заболевания сократилось в 1,6 раза. в 2018 г. зарегистрировано три случая кожной формы сибирской язвы в двух субъектах российской Федерации -республиках дагестан (1) и тыва (2). вспышки инфекции среди сельскохозяйственных животных и людей также зафиксированы в государствах ближнего зарубежья -грузии, казахстане, китае, кыргызстане и украине. эпизоотолого-эпидемиологическое неблагополучие по сибирской язве отмечено в ряде стран азии и африки. заражение людей происходило в результате контакта с больными и павшими животными в процессе убоя и разделки туш, а также употребления в пищу зараженного мяса. уровень заболеваемости животных и людей сибирской язвой в российской Федерации в 2019 г. будет зависеть от полноты реализации планов по профилактике сибирской язвы и при их максимальном выполнении не будет превышать регистрации единичных случаев.Ключевые слова: сибирская язва, вспышка, заболеваемость, Bacillus anthracis.Abstract. Analysis of the anthrax incidence in the Russian Federation over the period of 2009-2018 showed that the infections among the population were recorded in 14 regions of 6 Federal Districts. 23 anthrax outbreaks among people were revealed, where 90 people got sick with 3 lethal outcomes. In comparison to the previous ten-year period (1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008), the number of cases of the disease was reduced by 1.6 times. Three cases of cutaneous anthrax were registered in two constituent entities of the Russian Federation in 2018 -the Republic of Dagestan (1) and the Republic of Tyva (2). Outbreaks of infection among livestock animals and people were recorded in such neighboring states as Georgia, Kazakhstan, China, Kyrgyzstan, and Ukraine. Epizootiological and epidemiological instability as regards anthrax was observed in several countries of Asia and Africa. Human infection occurred as a result of contact with ...

BackgroundBacillus anthracis is a causal agent of a zoonotic disease relevant for many countries, and is an agent of bioterrorism. Meanwhile, the reasons for the dependence on tryptophan of some strains with altered virulence have not been established with an almost complete absence of information on the tryptophan operon of this pathogen. In this study, we report gene variability and the structure of the tryptophan operon in B. anthracis strains of the three main lineages.ResultsFor in silico analysis we used 112 B. anthracis genomes, including 68 of those available at the GenBank database and 44 sequenced at our institute. The B. anthracis tryptophan operon has an ancestral structure with a complete set of seven partially overlapping genes. The results show that the variability of all seven tryptophan operon genes is determined by the presence of single nucleotide polymorphisms and InDels. The trpA genes of strains of the main lineage B and trpG genes of strains of the C lineage are pseudogenes and the proteomes lack the corresponding enzymes of the biosynthetic pathway, which may explain the dependence of the strains of line B on tryptophan. ConclusionIn this study, the differences in tryptophan operon genes for B. anthracis strains belonging to different main lineages were demonstrated for the first time. Mutation in the gene of the tryptophan synthase subunit alpha can explain the dysfunction of this enzyme and the dependence on tryptophan in strains of the main lineage B. Identified features suggest a further study of the dependence on tryptophan in B. anthracis strains of the main lineage B and may be of interest from the point of view of intraspecific evolution of the anthrax pathogen.

The results of the analysis of epidemiological and epizootiological situation on anthrax in the Russian Federation and in the world in 2019 are presented in the paper. The forecast of morbidity rates in the Russian Federation for 2020 is made. In 2019, five cases of cutaneous anthrax were registered in the Russian Federation in two regions of the North Caucasian Federal District – Republic of Dagestan (4) and Stavropol Territory (1), which is two cases plus as compared to 2018. Outbreaks of infection among livestock animals and humans were recorded in such neighboring countries as Azerbaijan, Armenia, Belarus, Kazakhstan, Kyrgyzstan and Tajikistan. The unfavorable epizootiological situation on anthrax was observed almost everywhere. The highest incidence rates among wild and livestock animals were found in a number of countries in Asia and Africa. Anthrax among people was registered mainly in African countries, infection occurred mainly by alimentary route, less often – through contact with carcasses, meat of animals. Anthrax morbidity rates among animals and humans in the Russian Federation in 2020 will be largely determined by the completeness of registration and coverage with specific immunization of livestock animals and groups of people under professional risk of infection and, if measures are fully implemented, incidence will not exceed single cases.

A review of the epizootiological and epidemiological situation on anthrax in the world in 2020 was carried out. In the Russian Federation, five cases of human infection with cutaneous anthrax were registered in the entity of the North Caucasian Federal District – the Republic of Dagestan. A challenging situation was noted in the territory of border states – Azerbaijan, Georgia, Kazakhstan, Kyrgyzstan and Ukraine. Epizootics of anthrax among livestock and wild animals were identified mainly in African countries. At the same time, the largest number of confirmed human cases was detected in Africa (Zimbabwe, Kenya) and Asia (Indonesia). The infection of individuals with the causative agent of anthrax was primarily associated with the ingestion of meat from sick and dead anthrax animals, contact with animals during forced slaughter, skinning and processing of contaminated meat. The incidence of anthrax in the Russian Federation in 2021 will be determined by the realization of the planned volumes of preventive measures and, provided they are properly implemented, will be limited to identifying sporadic cases of infection that are potentially possible within the limits of certain regions of Russia.