Objective To evaluate the results of extracorporeal shockwave lithotripsy (ESWL) versus retrograde intrarenal surgery (RIRS) for the treatment of calcium oxalate nephrolithiasis, as well as the damaging effects on renal function, taking into account the dynamics of blood cystatin C and urine beta2-microglobulin.Material and Methods Of 94 patients with calcium oxalate nephrolithiasis aged 23–78 included in the study,  42 patients were classified as having undergone ESWL (group I) and 52 patients as having undergone RIRS (group II). Group II patients were then stratified into subset 2A (n = 32) as having undergone RIRS through rigid ureteroscope and subset 2B (n = 20) as having undergone RIRS through flexible ureteroscope. We performed plain urography and nephrosonography at 24–48 hours postoperatively and unenhanced computed tomography 4–6 weeks after surgery. We measured concentrations of serum cystatin C and urinary beta2-microglobulin as a marker for kidney damage. In group I, samples of peripheral blood andurine were taken before and after the first, third sessions and 30 days after the last ESWL session. In group  II, samples were analyzed before surgery, on the first and 30th postoperative days.Results The average size of calculi in the group with RIRS was 16.91 ± 2.79 mm, in the group with ESWL  12.31 ± 2.27 mm. The need for reoperation after RIRS was 19.2%, which was lower than after ESWL. Stone-free effect (no stones, or residual stones less than 3 mm) was observed in 95% of cases in patients with RIRS, and in 78% with ESWL. Group I patients demonstrated an increase in the blood leukocytes total number more often than subsets 2A (rigid RIRS) and 2B (flexible RIRS) patients. Leukocyturia was also a more common complication in group I. In the RIRS group, there was no statistically significant change in the level of blood cystatin C and urine beta2-microglobulin, on the contrary, a moderate increase in the endogenous marker of cystatin C was noted after one ESWL session. The increase in urine beta2-microglobulin levels in patients after the first and third ESWL sessions was significantly higher than after RIRS.Conclusion Flexible RIRS may be suggested as the preferred procedure for patients requiring additional protection of renal function in the treatment of renal stones less than 20 mm. ESWL of stones less than 20 mm can be used as an alternative treatment, since it is characterized by a rather long period of stone eradication from the urinary tract, a high frequency of residual calculi after the procedure, and also has a damaging effect on the renal tissue.

Currently, therapeutic interventions for erectile dysfunction in chronic prostatitis encounter a number of obstacles due to the lack of system-structural approach to sex pathological syndromes so new possibilities of correction of sexual disorders should be explored adequately influencing all the hierarchical levels to ensure the copulatory cycle. The aim of the study is a pathogenetic substantiation of the system magnetic therapy in treatment of patients with chronic prostatitis with erectile dysfunction. Materials and methods. Monitoring of 40 patients with chronic prostatitis with erectile dysfunction aged 22 to 45 years was carried out. All patients taking physical therapy, prostate massage, psychotherapy correction of sexual maladjustment had a course of system magnetic therapy on Magnitoturbotron «EOL» in the «Standard» mode, the rotational speed of the magnetic field of 100 Hz in 1 Hz steps, the direction of rotation of the magnetic field was direct, clockwise, the maximum value of the magnetic field - 1.5-2.0 mT for 15 minutes a day in an amount of 15 procedures. Results. Application of the system of magnetic therapy for chronic prostatitis with erectile dysfunction has a direct effect on the prostate, helping to reduce edema, leukocyte infiltration and glands venules thrombosis and has antiplatelet activity, improving peripheral blood circulation and lymph flow, on the other hand, it increases the duration of erections, improves psychophysical and emotional state. The result is a normalization of the frequency of regular coitus, with the final phase of ejaculation, an improvement of mental and physical and emotional health, which is fundamental in terms of pathogenetic therapy of CP with erectile dysfunction. In addition surveys’ matrix correlation analysis carried out on a scale IIEF showed a clear relationship of the life quality improvement and the disappearance or significant decrease in the severity of pain, increased duration of erection and improvement of the functional status of the prostate.