No abstract

IgG4-related sclerosing disease of the larynx (IgG4-SD) is a recently described immunodependent systemic pathology characterized by diffusive or focal inflammatory infiltration of the affected organs and tissues by plasma cells expressing IgG4; it is accompanied by the subsequent development of obliterative phlebitis and fibrosclerosis associated with the increase of the serum IgG4 level. According to the recently published materials, the disease can also develop in the respiratory system. The present article describes the first documented case of IgG4-related sclerosing disease with the isolated lesion of the larynx. The diagnosis was established based on the results of the comprehensive examination that made it possible to exclude systemic lesions, to determine the IgG4 level in the serum, and to carry out the immunohistochemical study of the histological preparations stained for the detection of IgG4-releasing plasmocytes. After verification of the diagnosis, the patient underwent a course of systemic hormonal therapy that resulted in the stable clinical and roentgenological remission of the disease that persists up to the present time.

Цель исследования -оценка эффективности и безопасности фавипиравира для лечения новой коронавирусной инфекции (COVID-19) легкого и среднетяжелого течения.Материал и методы. Проведено открытое рандомизированное многоцентровое клиническое исследование с активным контролем у амбулаторных и госпитализированных пациентов с COVID-19 легкого и сред-

The objective of the present work was to evaluate the effectiveness of the application of the inducer of endogenous interferon synthesis in the course of the combined treatment of the adult patients presenting with laryngeal papillomatosis. A total of 50 patients with this pathology were admitted and examined at the ENT Clinics of I.M. Sechenov First Moscow State Medical University and M.F. Vladimirsky Moscow Regional Research Clinical Institute during 24 months. The patients comprising group 1 (n=25) were treated with the use of cold plasma surgery and the inducer of endogenous interferon synthesis while those included in group 2 (n=25) received only surgical treatment. It was shown that the combined treatment including the surgical step (cold plasma surgery) followed by the treatment with the inducer of endogenous interferon synthesis to prevent relapses makes it possible to reduce the number of secondary surgical interventions, increase the duration of the intervals between relapses, and decrease the content of types 6 and 11 human papilloma virus in the saliva.

Urrently, the problem of foreign bodies in the airways of children continues to be relevant. Aim - to assess the effectiveness of diagnostics and treatment of children with foreign bodies in tracheobronchial tree. Materials and methods. In the Department of otorhinolaryngology, the SBHI of MAMRRCI n.a. M.F. Vladimirskiy, we performed an integrated research of 189 children of different age, who had aspirated foreign bodies in the airways. We studied anamnestic, clinical, roentgenological and endoscopic criteria for the diagnosis of this pathology; we also studied the frequency of clinical complications caused by aspiration. Results. Follow-up observation of these children shows a significant frequency of remaining changes in the lungs after removal of foreign bodies. Discussion. In our opinion, for correct diagnosis and provision of qualified care to sick children it is necessary to raise awareness of parents and primary care physicians about the dangers of this pathology. If there is a reason to suspect a foreign body in the airways, consultation in a specialized institution is vitally important. The only correct method of treating children with foreign body in the airways, even at the slightest suspicion, is timely performed tracheobronchoscopy.