Aim:The aim of this work was a comparative research of trace element structure of various organs of three Pulmonaria species. Materials and Methods: The aerial parts of the most widespread plants of genus Pulmonaria such as Pulmonaria officinalis L., Pulmonaria obscura Dumort. and Pulmonaria mollis Wulf. ex Hornem., which were collected in ending of flowering and were used as the research objects. The amount of trace elements (B, K, and Ti) was determined by means of mass spectroscopy with inductively coupled plasma. Results: The data clustering has shown that floral shoots and rosellate leaves possess essentially various trace element status. At the same time, the trace elements' status of organs of researched plants poorly depends on a taxonomic position of the plant. Thereupon, it is obvious that pharmacological activity is defined by organs of plants from which medicines were made, but not by a species of the used plant. Conclusions: The significant distinction in pharmacological activity of preparations depends on the trace elements' status of used medicinal vegetative raw materials.

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Obzory po kliniceskoj farmacologii i lekarstvennoj terapii [Reviews of clinical pharmacology and drug therapy] M 71Abstracts. PHYTOPHARM 2012 tent of trace elements. The aerial parts of 55 different plants of family boraginaceae, which were collected on the Eurasian continent, were used as the research objects. besides, various parts of plants of genus Pulmonaria which possessed the different pharmacological activity were used as objects of research too. The amount of the trace elements in the researched object was determined by means of inductively-coupled plasma mass spectroscopy. it was determined the content of 59 elements. As a result it was established that the dividing of elements into clusters in a hierarchical tree correlates with the systematic position of plants (factor of correlation 0,92). besides, the dividing of elements into clusters for various parts of Pulmonaria correlates with pharmacological activity of the phytomedicines which were made from these parts. Thus, the offered method of the analysis of the trace element structure of a plant allows more effectively looking up the new plants which will be sources of the essential elements. The development cycle of Pulmonaria mollis Wulf ex hornem can be divided into 2 periods -the first one is a short period from germination to the end of the fruiting stage, during which the floriferous shoots are developing; and the second one is a long period during which the root leaves are growing from underground resting buds. The medicines made from floriferous shoots have an antianemic activity. At the same time, the medicines made from the root leaves have expectorant activity. The aim of work is the characterization of phenol compounds of these parts of the plant. The floriferous shoots and the root leaves were collected in the Novosibirsk region. The raw materials were dried before analysis. The amount of phenolic compounds was measured by means of hPlC. identification of components was done by comparison with the standard substances. PHENOLIC COMPOUNDS OFfor the first time dihydroquercetin was discovered among the phenolic compounds of floriferous shoots, and vicenin in the root leaves. it is noteworthy that dihydroquercetin possesses strong anti-hemorrhagic action while vicenin has mainly an expectorant action. Thus, the various pharmacological activities of medicines made from theinvestigated plant parts of P. mollis could be connected with the different contents of phenolic compounds.

ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава РоссииВ статье представлено исследование химического состава лекарственного растительного сырья травы гармалы обыкновенной. Различными методами установлено наличие в составе алкалоидов, флавоноидов, дубильных веществ конденсируемой природы, стероидных сапонинов и кумаринов. Определено количественное содержание соединений: алкалоидов в пересчете на пеганин -3,8 %, флавоноидов в пересчете на гиперозид -0,37 %, хлорофилла-а -0,034 %, дубильных веществ в пересчете на катехин -2,1 %, кумаринов -5,8 %. Многообразие химического состава гармалы обыкновенной позволяет рассматривать ее как перспективное лекарственное растение.