Study of the effects of 2- and 10-min acupuncture on skin structures in acupuncture points on the upper limb and trunk of outbred albino rats showed that changes in the monoamine status of the skin appeared as early as 15 min after acupuncture. However, the effects in points GV14 and LI11 were different: skin structures in acupuncture point LI11 reacted sooner and more intensively. Acupuncture caused opposite changes in the serotonin index in different structures of the skin in acupuncture points.

Objective. We studied mast cells and neuroendocrine cells of the skin of adults in the area of the acupuncture points (AP) and outside them. Material and methods. Using the Unna method (polychrome toluidine blue dye), mast cells were detected in the skin. Conducted immunohistochemical study using monoclonal antibodies to neuron-specific enolase and synaptophysin in order to identify neuroendocrine cells. Research results. Analyzed data on the distribution of mast cells in the skin in the area of the acupuncture points in an adult. It was revealed that the distribution of mast cells in the dermis and the hypodermis differs depending on the localization of the acupuncture point. Fat cells take in maintaining homeostasis and regulation of metabolism in the skin. NSE- and synaptophysin-positive cells were detected in the basal layer of the epidermis, in the area of the the muscles that raise the hair, in the area of the hair follicles; in the secretory terminal regions of the sweat glands, as well as outwards from the basement membrane of these regions between the myoepithelial cells. A part of the neuroendocrine cells is in contact with nerve waves. Expression of NSE and synaptophysin depends on AP localization. In AP of the skin of the abdomen and upper limb, a more pronounced expression of NSE and synaptophysin is observed than at the acupuncture points of the skin of the face. The expression of NSE in the structures of the skin in the area of the acupuncture points is more pronounced than the expression of synaptophysin. In the dermis revealed structureless spaces surrounded by mast cells, nerve fibers, blood vessels.

The effectiveness of acupuncture contributing to stimulation of morphological organization and altering the dynamics of histamine in the spleen of mice already in the first days after treatment was validated using the methods of luminescent and light microscopy.

In the modern world, the number of elderly people with various diseases is growing, they need an appropriate care. Care implementation requires special knowledge, mental and economic expenditures. Ensuring a decent old age for the elderly is one of the problems of modern society. Comprehensive geriatric assessment is a multidimensional interdisciplinary diagnostic process for assessing the physical, psychological, functional and socio-economic problems of elderly people in order to develop a comprehensive individual plan for their treatment and rehabilitation. Comprehensive geriatric assessment benefits the elderly population, but the effectiveness of comprehensive geriatric assessment to improve the life quality of the elderly remains unclear. The article provides an overview of studies devoted to studying the effectiveness of using comprehensive geriatric assessment. The article discusses the influence of a comprehensive geriatric assessment on determining the life quality of the elderly, the duration of their stay in the hospital, and relieving the caregivers' burden. In addition, the influence of a comprehensive geriatric assessment on the ability to determine life expectancy, to conduct early diagnosis of major geriatric syndromes, the risk of morbidity and mortality in elderly patients is being considered. It is important that on the basis of a comprehensive geriatric assessment, appropriate rehabilitation programs can be drawn up, and technologies for rehabilitation can be determined.

Often used in medical practice drug Afobazol has a wide range of actions. The paper describes the morphological changes of neuroamine-containing structures of the thymus of white rats with long-term (8 weeks) afobazole administration. By fluorescent histochemistry was determined by the content of catecholamines, histamine, and serotonin in the structures of the thymus. Under the influence of afobazole, the luminescent picture in the structures of the thymus changes, the clear boundary between the cortical and medullary substance of the thymus lobe is erased. The introduction of Afobazole leads to a decrease in the concentration of biogenic amines in premedullary GLA and an increase in the concentration in the microenvironment, which indicates a decrease in the amino-producing properties of these cells and the release of neurotransmitters from GLA.