The increase in the incidence of type 1 diabetes (T1D), especially in children <5 yr of age, reported over the past decade can be attributed to changes in environmental factors (either quantitative or qualitative) rather than to an effect of genetic factors operating in such a short period of time. The notable increase in the incidence of type 2 diabetes (T2D) in children and adolescents is very likely the consequence of an increasing sedentary lifestyle and an increase in obesity, which has been occurring in developed countries. An increase in the number of children and adolescents with a mixture of the two types of diabetes has recently come to light (i.e., subjects who are obese and/or with signs of insulin resistance as well as positive for markers of autoimmunity to beta cells), although the epidemiological data supporting such a conclusion are sparse. Under the current classification, it is difficult to define the type of diabetes affecting these young subjects, who might be classified as T2D because they are obese and insulin resistant but also as T1D because of the presence of autoantibodies to beta cells. These subjects show an overlapping diabetes phenotype typical of both T1D and T2D, suggesting that the current classification of diabetes should be revised to take into account this new form of diabetes, which has been called 'double diabetes' or 'hybrid diabetes'. In this review, we report recent findings on the increasing rates of all forms of diabetes in the young population, including unpublished data collected in Russia.

This is the first study to report on validated incidence data for T1D in Moscow. We conclude that the incidence of T1D in Moscow is comparable to that of those European countries having intermediate incidence rates, and that the incidence is increasing.

ГБОУ ВПО Красноярский государственный медицинский университет имени проф. В. Ф. Войно-Ясенецкого Министерства здравоохранения РФ, ректор-д. м. н., проф. И. П. Артюхов; кафедра поликлинической терапии, семейной медицины и ЗОЖ с курсом ПО, зав.-д. м. н., проф. М. М. Петрова; кафедра физиологии им. проф. А. Т. Пшоника, зав.-д. м. н., проф. А. А. Савченко; 2 ФГБНУ НИИ медицинских проблем Севера, и.о. директора-д.м.н., проф. С.В. Смирнова; лаборатория молекулярно-клеточной физиологии и патологии, зав.-д.м.н., проф. А.А. Савченко. p%'>,%. Статья посвящена проблеме коморбидности острого инфаркта миокарда (ОИМ) и расстройств аффективного спектра. Представлен обзор последних крупных исследований по влиянию депрессии на ОИМ, механизмах взаимосвязи депрессии и ОИМ и влияние сопутствующих депрессивных расстройств на клиническое течение и прогноз больных ОИМ. j+>7%";% 1+." : острый инфаркт миокарда, тревожно-депрессивные расстройства.

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