The article considers the measured values of the level of MMP-1, MMP-8 and MMP-9, and of their tissue inhibitor Type I (TIMP-1) in the blood serum and mixed saliva samples of 78 patients (31 women -36.2 %, 47 men -63.8 %) suffering from odontogenic phlegmons in the oral and maxillofacial region. The study indicators were assessed through the enzyme-linked immunosorbent assay using diagnostic sets R&D Diagnostics Inc. (USA). An uncontrolled hyperactivation of metal proteinases as one of the components of the systemic infl ammatory response in case of phlegmon-related complications in the oral and maxillofacial region, as well as development of the sepsis syndrome were studied and it was determined that it results in distortion of the processes of reparative hystogeny and compel us to employ new approaches to the treatment of this type of patients (Tab. 2, Fig. 1

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In this work, the solubility dependence of radioactive baric samples under influence of microwave radiation (MWR) has been investigated at various concentrations of HCl after irradiation of BaO target at a flux of thermal neutrons. It is established that the use of MWR for dissolution of a sparingly-soluble barium oxide will accelerate a dissolution process at almost an order of magnitude in comparison with usual heating. Each time after separation of the 131Cs from radioactive barium solution analyses on radionuclide purity of the 131Cs product solutions were carried out.

Subject. The subject of the study is the cytokine profile of saliva in violation of mucosal immunity in patients with chronic generalized periodontitis and concomitant type II diabetes mellitus. Objectives. The goal was to assess local levels of cytokines: tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), transforming growth factor-beta 1 (TGF-β1), interleukin-4 (IL-4), interleukin-17 (IL-17) in patients with chronic generalized periodontitis without concomitant pathology (group I), with chronic generalized periodontitis and type II diabetes mellitus (group II), as well as in patients without signs of periodontitis, but with established type II diabetes mellitus ( III group). Methodology. 126 patients were examined, including: 47 people – group I, 49 people – group II and 30 people – group III. The control group consisted of healthy volunteers (30 people). Patient saliva was used as the research material. The levels of the studied cytokines TNF-α, IFN-γ, TGF-β1, IL-4, IL-17 were determined by the sandwich variant of enzyme-linked immunosorbent assay using specific reagents from R&D Diagnostics Inc (USA). Results. In patients of all studied groups, a significant increase in TNF-α, IFN-γ, IL-4 and IL-17 was found. In the group of patients with chronic periodontitis, a more pronounced increase in TNF-α, IFN-γ, TGF-β1 and IL-17, as well as an increase in the ratio of pro- and anti-inflammatory cytokines, was registered. Conclusion. The data obtained can be considered as promising markers for the personification of the prognosis for the development of chronic generalized periodontitis in type II diabetes mellitus.

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