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The formation of organogels and microemulsions of lecithin in the presence of a biocompatible cosurfactant, oleic acid, was studied. Low content of oleic acid ([oleic acid]/[lecithin] < 0.1) in the lecithin–oleic acid–dodecane–water system leads to an expansion of the region of existence and to a decrease in the viscosity of lecithin organogels. At high contents of oleic acid ([oleic acid]/[lecithin] > 0.6), low‐viscosity microemulsion exists in the system. Phosphatidylethanolamine, lysophosphatidylcholine, and other phospholipids that are present as impurities in the commercial samples of soybean lecithin can act as cosurfactants. For the first time, the formation of lecithin organogels in the systems containing commercial samples of soybean lecithin with phosphatidylcholine concentrations of 69.3 wt% (Lipoid S75) and 52.9 wt% (Lipoid S45) and saturated aliphatic hydrocarbons is demonstrated. The gelation is observed at T =25 °C in octane, decane, dodecane, and hexadecane for Lipoid S75 and in dodecane and hexadecane for Lipoid S45. A decrease in the degree of purification of lecithin leads to an expansion of the regions of existence of the organogels and to a reduction of their viscosity.

No abstract

Influence of a new protein-peptide complex on promoting skin wound healing in male BALB/c mice was studied. Protein-peptide complex, extracted from Sus scrofa immune organs, was percutaneously administered using two methods: by lecithin gel-like liquid crystals and by liquid microemulsion. On the fifth day, wound closure in mice with a linear wound model become faster in group (less 2 days comparison to other ones), which was treated with lecithin liquid crystals carrying the protein-peptide complex. This promoting healing can be caused by resorption of bioactive high-molecular compounds the animal skin. In mice with the linear wound model, the tensile strength of the scars were respectively higher both in mice, treated using lecithin liquid crystals with protein-peptide complex, and in mice, treated using microemulsion containing protein-peptide complex, by 215.4% and 161.5% relative to the animals, which did not receive bioactive substances for wound treatment. It was associated with the regeneratory effects of tissue- and species-specific protein-peptide complexes, including α-thymosin Sus scrofa (C3VVV8_PIG, m / z 3802.8) and other factors, which were described as parts of the new extracted complex. This reveals that percutaneous administration of the complex reliably activates local regenerative processes in animals.

Проведен анализ динамики публикаций в базе данных ScienceDirect за 1997–2016 годы в областях, связанных с применением наночастиц и наноструктур для адресной доставки лекарственных веществ и определены наиболее динамично развивающиеся направления исследований. Согласно данным, представленным в статье, наиболее востребованы на сегодняшний день (т.е. характеризующиеся быстрым ростом количества публикаций и большим общим числом публикаций) такие направления исследований, как применение для адресной доставки лекарственных веществ магнитных наночастиц, наночастиц диоксида кремния, наночастиц полимеров, твердых липидных наночастиц, дендримеров, полимерных мицелл и мицелл поверхностно-активных веществ. Можно прогнозировать, что в ближайшие 10–20 лет эти направления будут и дальше развиваться, но, вероятно, с более низкой скоростью роста числа публикаций, которая характерна для направлений из первой группы.