Microemulsions and Lyotropic Liquid Crystals of Lecithin as Systems for Transdermal Drug Delivery

Мурашова, Н. М.; Трофимова, Е. С.; Kostyuchenko, M. Yu.; Мезина, Е. Д.; Yurtov, E. V.

doi:10.1134/s1995078019010075

Cited by 9 publications

(10 citation statements)

References 13 publications

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“…Lecithin liquid crystals (LLC) were prepared as it was described earlier ( Murashova et al, 2019 ): 7.0 g of “Moslecithin” phospholipid concentrate (Vitaprom, Russia, containing 97 wt% phospholipid complex 22 wt% of which is phosphatidylcholine (lecithin), and vegetable oils (Botanica, Russia: 1.0 g of Persea gratissima oil and 0.5 g of Melaleuca alternifolia essential oil). Then, 1.5 ml of distilled water or 1.5 ml of distilled water and 0.3 g of methyluracil, or 1.0 ml of distilled water and 0.5 ml of protein-peptide complex (5 wt% protein) was added to the sample.…”

Section: Methodsmentioning

confidence: 99%

“…The results of polarizing microscopy showed that the samples had a texture typical for lamellar liquid crystals. Viscosity of liquid crystals of such composition was hundreds and tens of Pa·s at shear rates of 0.1–1.0 s-1 ( Murashova et al, 2019 ).…”

Section: Methodsmentioning

confidence: 99%

“…Liquid microemulsions (LME) were prepared as it was described earlier ( Murashova et al, 2019 ): 2.0 g of Moslecithin phosphate lipid concentrate was dissolved in a mixture of 3.42 g of Vaseline oil and 3.43 g of Persea gratissima oil (Botanica, Russia) at 60 °C in a closed flask with constant stirring in a magnetic stirrer, RCT basic (IKA, Germany) at 200 rpm for 80 min, until complete dissolution of the phospholipid concentrate. Then, 0.7 g of oleic acid and 0.45 g of Melaleuca alternifolia essential oil (Botanica, Russia) were added to the solution that had been cooled to 20 °C, which was then mixed at 100 rpm at 25 °C.…”

Section: Methodsmentioning

confidence: 99%

“…Hydrodynamic diameter of the droplets for the sample, containing water, was 21 ± 3 nm and for the sample, containing protein extract, was 44 ± 2 nm. Viscosity of microemulsions of such composition was in the range 1.0–0.1 Pa·s at shear rates of 1–10 s −1 ( Murashova et al, 2019 ).…”

Section: Methodsmentioning

confidence: 99%

“…They form spontaneously when the necessary components are mixed, and can exist indefinitely at a constant composition and temperature, they are easy to prepare. Lecithin liquid crystals have a higher viscosity and provide a lower rate of release of water-soluble substances, than lecithin microemulsions ( Murashova et al, 2019 )…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Sus Scrofa immune tissues as a new source of bioactive substances for skin wound healing

Basov

Fedulova

Vasilevskaya

et al. 2021

Saudi Journal of Biological Sciences

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Influence of a new protein-peptide complex on promoting skin wound healing in male BALB/c mice was studied. Protein-peptide complex, extracted from Sus scrofa immune organs, was percutaneously administered using two methods: by lecithin gel-like liquid crystals and by liquid microemulsion. On the fifth day, wound closure in mice with a linear wound model become faster in group (less 2 days comparison to other ones), which was treated with lecithin liquid crystals carrying the protein-peptide complex. This promoting healing can be caused by resorption of bioactive high-molecular compounds the animal skin. In mice with the linear wound model, the tensile strength of the scars were respectively higher both in mice, treated using lecithin liquid crystals with protein-peptide complex, and in mice, treated using microemulsion containing protein-peptide complex, by 215.4% and 161.5% relative to the animals, which did not receive bioactive substances for wound treatment. It was associated with the regeneratory effects of tissue- and species-specific protein-peptide complexes, including α-thymosin Sus scrofa (C3VVV8_PIG, m / z 3802.8) and other factors, which were described as parts of the new extracted complex. This reveals that percutaneous administration of the complex reliably activates local regenerative processes in animals.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Sus Scrofa immune tissues as a new source of bioactive substances for skin wound healing

Basov

Fedulova

Vasilevskaya

et al. 2021

Saudi Journal of Biological Sciences

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show abstract

Investigation of Nanostructure and Interactions in Water-in-Xylene Microemulsions Using Small-Angle X-ray and Neutron Scattering

et al. 2023

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The ability to modulate the size, the nanostructure, and the macroscopic properties of water-in-oil microemulsions is useful for a variety of technological scenarios. To date, diverse structures of water-in-alkane microemulsions stabilized by sodium bis(2-ethylhexyl) sulfosuccinate (AOT) have been extensively studied. Even though the decisive parameter which dictates the phase behavior of micremulsions is the nature of the continuous phase, relatively very few reports are available on the structure and interactions in the microemulsions of aromatic oil. Here, we present a fundamental investigation on water-in-xylene microemulsions using small-angle neutron scattering (SANS) at a fixed molar ratio (ω) of water to AOT. We elucidate the microstructural changes in the water-AOT-xylene ternary system at dilute volume fractions (Φ = 0.005, 0.01, 0.03), where the droplet−droplet interactions are absent, to moderately concentrated systems (Φ = 0.05, 0.10, 0.15, and 0.20), where colloidal interactions become important. We also characterize the reverse microemulsions (RMs) for thermally induced microstructural changes at six different temperatures from 20 to 50 °C. Depending on the magnitude of Φ, the scattering data is found to be well described by considering the RMs as a dispersion of droplets (with a Schulz polydispersity) which interact as sticky hard spheres. We show that while the droplet diameter remains almost constant with increase in the volume fraction, the attractive interactions become prominent, much like the trends observed for water-in-alkane microemulsions. With increase in temperature, the RMs showed a marginal decrease in the droplet size but no pronounced dependence on the interactions was observed with the overall structure remaining intact. The fundamental study on a model system presented in this work is key to understanding the phase behavior of multiple component microemulsions as well as their design for applications at higher temperatures, where the structure of most RMs breaks down.

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Microemulsions of Lecithin with Various Vegetable Oils for Medical Use

Nguyen,

Pyaterneva,

Cheryakova

et al. 2023

High Energy Chem

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Microemulsions and Lyotropic Liquid Crystals of Lecithin as Systems for Transdermal Drug Delivery

Cited by 9 publications

References 13 publications

Sus Scrofa immune tissues as a new source of bioactive substances for skin wound healing

Sus Scrofa immune tissues as a new source of bioactive substances for skin wound healing

Investigation of Nanostructure and Interactions in Water-in-Xylene Microemulsions Using Small-Angle X-ray and Neutron Scattering

Microemulsions of Lecithin with Various Vegetable Oils for Medical Use

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