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Aim. Study the dynamics of immunologic parameters in patients with chronic bacterial infections during various schemes of administration of Immunovac VP-4 vaccine. Materials and methods. Parameters of systemic immunity and levels of specific antibodies of various isotypes in blood sera and saliva against vaccine antigens of Staphylococcus aureus and Klebsiella pneumoniae were evaluated in patients (20 individuals, 18 - 50 years of age) distributed into 2 groups by vaccine administration type twice (before and 0,5 - 1,5 months after vaccine therapy course). Results. Local vaccination resulted in an increase of only IgA levels in saliva and both bacterial antigens, whereas parameters of systemic immunity before and after vaccination did not differ. Subcutaneous vaccination increased the level of sera antibodies of A- and G- isotypes against both bacterial antigens, normalized the decreased level of CD8" lymphocytes and an increased value of the immune regulating index; a tendency of increase of the percentage of CD3+ T-cells and reduction of the percentage of CD4+ T-helpers was observed. Conclusion. An optimal scheme of a combined vaccine therapy should be developed to obtain a complex effect, that would allow to simultaneously reach long-term local and systemic antibacterial immunity, as well as show immune modulating effect regarding cell compartment.

Psoriasis is an immune-mediated disease with a complex pathogenesis. The close relationship between the development of psoriasis and the adaptive immune response is already known. However, recent data have shown that innate immune cells also play an important role in the development of psoriasis. Congenital lymphoid cells, dendritic cells, T cells, NK cells, and NKT lymphocytes are activated in psoriasis, contributing to disease pathology through IL-17-dependent and independent mechanisms. During disease progression, T cells secrete proinflammatory cytokines that induce and exacerbate the course of psoriasis. T cells have memory cell properties that respond rapidly to secondary stimulation, which contributes to disease relapse. This article presents an overview of recent findings demonstrating the role of innate immunity in psoriasis.

Aim.To study the level of specific antibodies of different isotypes to the antigens of Staphylococcus aureus and Klebsiella рneumoniae in the serum, saliva and nazal secret and the concentration of IgA,sIgA,IgG in saliva from frequently and long-term ill children in nasal-oral administration of Immunovac VP-4.Materials and methods.Specific antibodies to S. aureus and K.pneumoniae, contained in saliva, nasal, and serum were determined by the method of enzyme immunoassay. Concentrations of immunoglobulins of classes G, A and sА in saliva were determined by radial immunodiffusion using a commercial kit produced by the NPC «Medical immunology».Results. The high level of specific antibodies contained in the serum and nasal secretions, the level of antibodies in saliva is negligible. The serum is dominated by IgG-isotype antibodies, saliva and nasal secret — antibodies of IgA-isotope. After the introduction of Immunovac VP-4 there was a statistically significant increase in the level of specific antibacterial antibodies in serum, saliva and nasal secret, and increasing levels of IgG and sIgA in saliva.Conclusion. Obtained data demonstratet that the nasal-oral scheme of administration of Immunovac VP-4 frequently and long-term ill children allowed to increase the level of specific antibodies in serum, saliva and nasal secret to bacterial antigens that are part of the vaccine and to normalize the local synthesis of IgG and sIgA, which play a major role in the protection of the respiratory tract and mucous membranes of the upper respiratory tract.