There are presented data on group cases of hemorrhagic fever with renal syndrome (HFRS) in the foci of distribution of mouselike rodents - the carriers of pathogenic genotypes of hantaviruses. A relationship between HFRS incidence and the period of acute manifestations of infection in rodents has been revealed. According to detection by RT-PCR specific RNA on substrates of environment there were designated the possible factors of transmission of the agent.

Results of the analysis of cases of hemorrhagic fever with renal syndrome (HFRS) in pregnant females recorded in the Primorsky Krai, clinical symptomatology of the disease, pregnancy outcome and neonatal state are presented. In case of mild course of HFRS a favorable outcome of the disease, which had not broken a normal course of pregnancy without consequences for the child was observed. Severe course of HFRS in pregnant females led to premature labors and subsequent death of a premature infant. Serologic examinations indirectly confirmed the absence of transplacental transmission of the virus from the mother.

On the base of long-term analysis ofprevalence of the hemorrhagic fever with renal syndrome (HFRS) and data of hantavirus infections in Apodemus mice - reservoirs ofpathogenic hantaviruses, the relation between of spatio-temporal peculiarities of prevalence of HFRS in Primorye Territory with activity of epizootic process in rodent populations during different phases of their population cycles has been established.

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