Currently, plasma medicine is a synthetic direction that unites the efforts of specialists of various profiles. For the successful formation of plasma medicine, it is necessary to solve a large complex of problems, including creating equipment for generating cold plasma, revealing the biological effects of this effect, as well as identifying and justifying the most promising areas of its application. It is known that these biological effects include antibacterial and antiviral activity, the ability to stimulate hemocoagulation, pro-regenerative properties, etc. The possibility of using the factor in tissue engineering and implantology is also shown. Based on this, the purpose of this review was to form a unified understanding of the biological effects and biomedical applications of argon cold plasma. The review shows that cold plasma, like any other physical and chemical factors, has dose dependence, and the variable parameter in this case is the exposure of its application. One of the significant characteristics determining the specificity of the cold plasma effect is the carrier gas selection. This gas carrier is not just an ionized medium but modulates the response of biosystems to it. Finally, the perception of cold plasma by cellular structures can be carried out by activating a special molecular biosensor, the functioning of which significantly depends on the parameters of the medium (in the field of plasma generation and the cell itself). Further research in this area can open up new prospects for the effective use of cold plasma.

Attempts to digitize samples and apply artificial intelligence and machine learning methods to analyze crystalloscopic (dried drops of biological fluids) and tesigraphic (dried drops of biological fluids with crystallogenic substance) facies have not yet been successful. In this regard, there is a need to develop a simplified algorithm for describing the facies of biological fluids, which can be used for a unified computer study of the results of crystallization of biological objects, which served as the purpose of the work. To develop and test the method presented in this paper, we used more than 16,000 images of dried biological fluids of the human and animal body, including both crystalloscopic and tesigraphic facies. The algorithm is based on determination of 4 main parameters (crystallizability, structure index, facies destruction degree and clearity of the marginal zone), graded on three-point scales. In addition, a facies integral parameter combining the values of all criteria is proposed.

The aim of the study was to clarify the features of adaptation of the cardiovascular system (by hemodynamic parameters) to the conditions of the earth's gravity in different periods of ontogenesis. Methods: The analysis was conducted for the number of age groups: up to 8 years (n=55), 9-14 years (n=68), 15-21 years (n=226), 22-35 years (n=326), 36-55 years for women and 36-60 years for men (n=658), up to 70 years (n=413) and over 70 years (n=198). The study of the cardiovascular system was carried out on the hardware and software complex "ANTHROPOS-CAVASCREEN" created by us on the basis of tetrapolar thoracic and regional rheography. Three orthostatic types of hemodynamics (hypokinetic, eukinetic and hyperkinetic) are determined by the ratio of minute blood volume standing/lying. Results: The age limit of transition to the increase in the severity of hyperkinetic organization of blood circulation (corresponding to the orthostatic type III of hemodynamics) is the first reproductive age (22-35 years). The age dynamics of the typological structure indicates that the orthostatic type of hemodynamics is a dynamic characteristic of the organization of blood circulation and it must be taken into account when assessing the circulatory state of the cardiovascular system. K E Y w o r d sage , hemodynamics, orthostatic type.

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