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ifp@isp.nsc.ru Diagnostic possibilitiesof rheological disorders in patients with diabetes mellitus is presented, based on the study of electrical and viscoelastic parameters of erythrocytes by dielectrophoresis using an electrooptical cell detection system. The most significant characteristics in the diagnosis of micro-rheological abnormalities in diabetes were the mean erythrocyte diameter, the amplitude of erythrocyte deformationat a frequency of 106 Hz, the degree of deformation at 0.5 x 106 Hz, the summarized parameters of viscosity and rigidity, the magnitude of the dipole moment, the electrical conductivity of cells (AUC 0.713-0.982). Discriminatory values of these indices for different degree of severity of rheological disorders in type 2 diabetes mellitus were obtained. Sensitivity (97.8 %) and specificity (86.7 %) were determined with the use of a set of erythrocyte parameters in order to diagnose the degree of microcirculatory disorders in comparison with the data on criteria for assessing the risk of vascular complications in diabetic patients proposed by the European Diabetes Association (EASD).

Представлены возможности оценки степени тяжести гемореологических нарушений у больных с ар-териальной гипертензией (АГ), основанной на исследовании параметров гемостаза, клеток красной крови с использованием диэлектрофореза. У пациентов с АГ увеличение риска венозных тромбоэмболических осложнений ассоциировано с ускорением лейкоцитарно-тромбоцитарной агрегации, повышением уровня фибриногена и снижением активности Xiiа-зависимого фибринолиза, что создает предпосылки для реоло-гических нарушений. Наиболее точное прогнозирование результата по степени тяжести гемореологических нарушений (дифференцировка умеренных и выраженных нарушений от легких) обеспечивается такими по-казателями электрических и вязкоупругих параметров эритроцитов (Er), как поляризуемость на высокой Sciences, Novosibirsk, e-mail: ifp@isp.nsc.ru the possibilities of assessing the severity of hemorheological disorders in patients with arterial hypertension, based on the study of parameters: hemostasis, erythrocytes (by dielectrophoresis). in patients with hypertension, as the risk of venous thromboembolic complications increased, acceleration of leukocyte-platelet aggregation, increased fibrinogen level and decreased activity of Xii-dependent fibrinolysis, which creates prerequisites for rheological disturbances, were revealed. the most accurate prediction of result according to severity of hemorheological disorders (differentiation moderate and expressed disorders from the lungs) is provided by such indicators of electric and viscoelastic parameters of erythrocytes, as the polarizability of red blood cells at a frequency of 106 Hz (AUC = 0,750 in), the speed of movement of cells to the electrodes (AUC = 0,746), deformation degree at a frequency of 5х105 Hz (AUC = 0,733), conductivity cell (AUC = 0,730), the generalized viscosity (AUC = 0,729), the index of aggregation of erythrocytes (AUC = 0,716), graduation according to the degree of strain at all frequencies (AUC = 0,716), generalized stiffness (AUC = 0,714), the deformation amplitude at frequency of 106 Hz (AUC = 0,711), the capacity of the cells (AUC = 0,693). the measure of specificity for different indices of erythrocytes is 75,4-99,3 % and a sensitivity of 84,1-98,6 %.Keywords: arterial hypertension, hemorheological disorders, electrical, viscoelastic parameters of red blood cells, hemostasis, leukocyte-platelet aggregation, hemolysis-aggregation test, the risk of thrombosis Артериальная гипертензия (АГ) встре-чается у 20-30 % взрослого населения, являясь очень распространённой кардио-васкулярной патологией, особенно у лиц старше 65 лет, достигая при этом 50-65 %. Будучи основной причиной сердечно-со-