The research is devoted to study clinico-laboratory implications and indicators of coagulating system of blood at patiens with liver cirrhosis associated with virus hepatitises B, C and D. The group of 100 patients were analyzed. At patients combined the lesion of a liver viruses HCV and HBV met identical frequency with a HBV-infection (34%). The hepatocellular carcinoma is taped in 8% of cases. At 50 patients with a cirrhosis in subcompansation stage researches of coagulating system of blood have been carried out. According to the developed coagulogram consumption coagulopathy development became perceptible.
ВведениеАктуальным для клинической практики являет-ся изучение инфекционного мононуклеоза (ИМ) как одного из наиболее распространенных забо-леваний, возникающих вследствие заражения ви-русами семейства Herpesviridae. Среди последних ведущее место в развитии данной патологии зани-мает вирус Эпштейна -Барр, при этом его доля в структуре респираторных инфекционных забо-леваний неуклонно растет.
The paper presents the results of clinical tests of the comparative estimation of tolerance, effectiveness and clinic-laboratory indices of chronic HBV and HCV patients Laifferon and Reaferon-ES treatment within a year (12 month). Less collateral effect caused by laifferon is stated. The results of effectiveness of Laifferon and Reaferon-ES treatment of the chronic HBV and HCV patients did not differ in compared groups.
This paper describes study of larynx microflora in patients with acute laryngtis and exacerbations of chronic laryngitis. Therapeutic algorithm based on bacteriologic examination data was developed reduce. New algorithm helps reduce sickness terms and to decrease prevalence of desease.123 patients of age from 18 to 60 were under observation: 43 patients with acute laryngitis and 80 patients with exacerbation of chronic laryngitis. 22 patients with acute laryngitis and 58 patients with exacerbation of chronic laryngitis underwent etiotropic treatment with antibiotics. The group of comparison with acute laryngitis (21 patients) and chronic laryngitis (22 patients) received treatment according to the conventional scheme.Bacteriologic examination of larynx mucous, clinical study and functional voice test (time of maximum vowels phonation) before and after treatment were carried out.As a result of the research it was established that the most common causative agent of acute and chronic inflammatory larynx diseases is S. aureus as a mono culture or combined with other bacterial associations (S. аnhemolyticus, Str. viridans etc.).After the end of antibacterial therapy we found symptoms as hoarseness, irritation, dry laryngopharynx, hyperemia and swelling of larynx mucous reduced eather in new treatment group than controlled group. Time of maximum vowels phonation (in seconds) also increased significantly.Sickness terms after prescription of new treatment was shorter than in comparison groups: (10.9 ± 7.9) days for acute laryngitis and (12.6 ± 7.3) days for chronic laryngitis respectively. Health index was 20.8 and 19.5% respectively.
ГОУ ВПО «СибГМУ Росздрава», кафедра инфекционных болезней ФПК и ППС и кафедра патофизиологии, г. Томск Резюме. Проведен сравнительный анализ иммунологических показателей у больных с HBVиндуцированным циррозом печени (ЦП) и больных с острым и хроническим вирусными гепатитами В (ОВГВ, ХВГВ). Продемонстрировано, что у больных с циррозом печени отмечается активация В-звена иммунитета (повышение содержания в крови CD22 + лимфоцитов, IL-4, циркулирующих иммунных комплексов), сочетающаяся с увеличением численности CD16-позитивных лимфоцитов и Т-дефицитом. Установлено, что наиболее выраженные различия регистрируются при сопоставлении иммунологических параметров у пациентов с ЦП и ОВГВ с последующей элиминацией вируса. При сравнении показателей у больных с ЦП и ХВГВ найденные различия не зависят от фазы репликации или интеграции вируса.
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