To determine the role of exogenic and endogenic factors in chronic obstructive pulmonary disease (COPD) forming 100 patients (50 patients are control group) were examined by means of clinical and genealogical researches, including family tree composition with analisis of 3—4 generations, genotyping on the most wide-spread α1-proteinase inhibitor (α1-PI) gene alleles (M, S, Z), definition of the α1-PI level in the serum. The role of exogenic factors (smoking, pollutants) have been confirmed in COPD forming, while primery α1-PI deficiency have been revealed only in 6% COPD patients. Therefore, further investigations of other genetic alleles in COPD patients are necessary.

The research is devoted to study clinico-laboratory implications and indicators of coagulating system of blood at patiens with liver cirrhosis associated with virus hepatitises B, C and D. The group of 100 patients were analyzed. At patients combined the lesion of a liver viruses HCV and HBV met identical frequency with a HBV-infection (34%). The hepatocellular carcinoma is taped in 8% of cases. At 50 patients with a cirrhosis in subcompansation stage researches of coagulating system of blood have been carried out. According to the developed coagulogram consumption coagulopathy development became perceptible.

We present data of clinical-genealogical study of patients with chronic obstructive bronchitis (82 people) and control group (108 people). Study of frequency of lung’s disease in parents and relatives of seek patients and patients from control group revealed the prevalence of bronchopulmonary pathology in the first group in comparison with the second. Study of frequency morbidity depending on the gender of descendents determined the significant prevalence in girls than in boys. Study of type of family burdening in seek patients revealed the prevalence of the type «seek mother, healthy father».