No abstract

Vitiligo is a chronic acquired disorder of skin pigmentation, characterized by the presence of sharply limited depigmented areas of the skin as a result of the progressive loss of melanocytes. The purpose of the work: increasing the effectiveness of treatment of patients with vitiligo by shortening the treatment period, ensuring the stability of results and reducing the number of complications with combined methods of treatment of a stable form of vitiligo with the use of cultured melanocytes and keratinocytes compared to methods approved by European standards and domestic orders. Study object and methods: 107 vitiligo patients aged 19 to 65 were under our observation. Depending on the method of treatment, the patients were randomly selected into two representative groups: the main group, which received treatment according to the developed method, and the comparison group, which received traditional treatment. When evaluating the results of treatment in examined patients 8 and 16 weeks after the start of therapy, more pronounced positive dynamics were found in patients of the main group, whose complex therapy included melanocyte-keratinocyte suspension (MCS) and automesoconcentrate (AMK). Conclusions: the analysis of the results of treatment of patients with vitiligo proved not only good tolerance, but also high efficiency of treatment when using, along with traditional therapy, cellular technologies.