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The problem of adequate antithrombotic therapy is considered when the INR time is in the therapeutic range of 70% or more. In the course of the study, the low efficiency and safety of patronage of patients taking vitamin K antagonists by general practitioners of medical institutions was illustrated. The total time spent by patients in the therapeutic range of INR for 2 years of follow-up was 36.9%, while increasing the risk of hemorrhagic and thromboembolic complications. The study proved the high clinical efficiency of the centralized INR monitoring system in the patronage of patients taking vitamin K antagonists. regardless of the distance of the patient from the medical institution. The average residence time of the INR in the therapeutic range obtained under the conditions of the system was 71.3%, which corresponds to the best world indicators. During its existence, the algorithm of the system's functioning has been repeatedly modified, the software complex of the system has been improved and refined. As a result, the monitoring system has become an effective, socially adapted tool for the prevention of thromboebolic complications in patients with cardiovascular diseases.

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