There were 46 children with chronic otitis media with effusion (OME) under the supervision. After carried out virologic research by immune-enzyme analysis, polymerase chain reaction, metod-immunofluorescence-antitel, prevalence Epstein-Barr virus infection — 41 person (89,1 %), a smaller part children with respiratory syncytial virus — 18 children (39,1 %) and adenovirus infections — 15 children (32,6 %) — are noted. All patients were undergone surgical treatment — middle ear bypass surgery, after the surgery the thirst group patients received antiviral drug while the second group patients received standard treatment. Inclusion antiviral drug into the OME treatment algorithm decreases terms of patient¢s treatment.