Supersensitive magnetometric systems based on low-temperature SQUIDs have been designed to conduct research in cardiology (magnetocardiography) and to examine distribution of magnetic nanoparticles in biologic objects. Such SQUID magnetometric systems are distinguished by their noise immunity enabling research in nonscreened rooms. High repeatability of research outcomes has been confirmed. The use of magnetocardiographic systems has permitted a new screening information technology to be developed to diagnose heart diseases at early stages. Magnetic imaging of heart’s action currents is an ideal way to test local electrical heterogeneity of myocardium. It is shown that magnetocardiography has a significant potential for both basic science of analysis of heart’s biosignals and clinical cardiologic practice. A SQUID magnetometric system measuring magnetic signals radiated by the organs of laboratory animals is described. Information technology for automatic recording and transforming magnetometric data has been developed; the measurement of signals over rats’ livers while injecting intravenously the nanoparticles of iron oxides and lead solutions are presented.

This paper describes the development of the magnetostatic inverse problem solution methods for studies of the magnetic field of human heart (magnetocardiography -MCG). A set of N different dipole sources is associated with the spatial distribution of the heart magnetic field parameters, measured in the observation plane.Methods: Estimation of the field sources quantity in the heart for a given time-point of the average cardiocycle is obtained after spatial-and-time analysis of the spatial gradients intensity of the magnetic field in the observation area (plane). Relative powers of the field sources have been obtained by plotting the Voronoi diagram. Mutual locations (coordinates) of the sources in the heart volume are obtained after examining the analytical solution of the magnetostatic inverse problem for each of the N magnetic dipoles.Results: The analytical solution of the magnetostatic inverse problem for several magnetic field sources, independently distributed in a 3D volume, has been obtained. The validity of the problem solution is supported by the results of numerical and physical simulations.Conclusions: Algorithm of the magnetostatic inverse problem solution is implemented as a software package for the magnetocardiograph and used for cardiology diagnosis.

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