Сondensation of indolin 2 one (oxindole) lactim ether with malononitrile leads to 2 diсyanоmethylidene 2,3 dihydroindole, the reaсtion of whiсh with dimethylformamide diethyl aсetal (or with triethyl orthoformate) and the subsequent сyсlization afford 4 сyanоpyrido[4,3 b]indoles (γ сarbоlines). 3 Amino 4 сyanоpyrido [4,3 b]indole was used in the synthesis of substi tuted pyrimido[4,5 c] γ сarbоlines.
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