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Summary. The aim of the work is to study the effectiveness of using interactive teaching methods and practical skills in the educational process, which will help improve the quality of training for students of the dental faculty at the Department of Internal Medicine of the Dentistry Faculty named after Professor M.N. Berezhnitsky.           Based on the study of the effectiveness of using interactive teaching methods and the development of practical skills in clinical pharmacology in the educational process in the fourth year of study on the Dentistry Faculty under the medical education reform demonstrate, that only a comprehensive approach to the study of clinical pharmacology with the assimilation of modern theoretical material, the development of practical skills at the patient’s bedside, and by solving situational problems, self-awareness of classroom and extracurricular work allows students to explore clinical pharmacology in accordance with the modern requirements of medical reform. The knowledge acquired at the department about pharmacokinetics, pharmacodynamics, interaction and side effects of drugs, effectiveness, safety of prescribed drugs and acquired practical skills contribute to the development of professionalism of a future specialist.

The condition of coagulation and platelet hemostasis in 125 patients with atrial fibrillation (AF) and with metabolic syndrome (MS) has been analysed. Сoagulation and platelet hemostasis in 125 patients with AF and MS under treatment with acetylsalicylic acid (ASA) (group 1), omega-3 polyunsaturated fatty acids (omega-3 PUFAs) (group 2) and ASA with L-arginine (3 group) during 2 months were measured. It was established that omega-3 PUFAs are more effective compared with ASA/aspirin with L-arginine and it promotes normalization of fibrinogen, soluble fibrin-monomer complexes (SFMK), D-dimer and improves the platelet aggregative activity (PAA).

Purpose – determination of coagulation hemostasis parameters depending on age and plasma endogenous insulin (EI) levels in the patients with different forms of atrial fibrillation (AF) and metabolic syndrome (MS). Materials and methods. The study involved 137 patients with paroxysmal, persistent and permanent forms of AF and with MS, including 28 patients – the middle age (group 1); 67 elderly patients (group 2) and 42 old age patients (group 3); 84 patients –with insulin resistance and 53 patients – without insulin resistance. An analysis of coagulation hemostasis plasma parameters was made according to prothrombin index (PtI), fibrinogen, soluble fibrin monomer complexes (SFMC) and D dimer levels by standard methods. Results. It was found that PtI level tends to increase with age. The most significant increase up to 25 % (p<0.05) was in the 3rd group of patients with spontaneous hyperinsulinemia (HI) and with paroxysmal AF. The plasma fibrinogen level tended to increase with age (р<0.1) and was increased by 1,5-2 times under reactive and spontaneous НI compared to the patients without insulin resistance (p<0.05), both in paroxysmal and in permanent forms of AF. Significant increase of SFMC level was detected in all patients, but there was greater extent in patients of the 2nd and 3rd groups with spontaneous HI (p<0.05) and with the permanent form of AF (p<0.05). Increased plasma D-dimer levels appeared typical for 40% of the patients of middle age and almost 50% in elderly and old patients, mainly in spontaneous HI (p<0.05). The presence of D-dimer in plasma was found in 40 %; 42 % and 54 % cases under paroxysmal, persistent and permanent forms of AF, respectively (p<0.05). Conclusions. Patients of older age groups regardless of AF type and under the presence of insulin resistance are characterized by hypercoagulable state formation and that manifested by increased plasma PtI, fibrinogen, SFMC and D-dimer levels compared to patients without insulin resistance.

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