The paper shows the results of studies conducted in order to determine the causes and mechanisms of the occurrence of such complicating factors as asphaltene-resinparaffin deposits, mechanical impurities, salts, equipment corrosion. The analysis showed that factors complicating the operation of pumps include significant removal of highly abrasive quartz sand layers, deposits in the pump and in the tubing string of precipitated asphaltene-resin-paraffin deposits and inorganic salts, as well as the aggressiveness of the formation waters that contribute to equipment corrosion. The authors of the article have developed new and upgraded previously known technologies to combat these factors and proposed appropriate recommendations.