Background: The aim of this study was to investigate the effect of the herbal medicine Canephron®N, particularly regarding its ability to prevent recurrences of cystitis, associated with E.Coli in women of child-bearing age. Methods: Ninety patients were randomised into two treatment groups. Both, the test group (n = 45) and the control group (n = 45), received an antibacterial therapy (fluoroquinolones) for 7 days determined by urine culture. Furthermore, in both groups general recommendations on preventing cystitis were made (sufficient liquid consumption, avoidance of hypothermia etc.). The test group received an additional Canephron®N therapy for 3 months (2 tablets, three times a day). Control examinations were conducted on day 7 and after 3, 6 and 12 months; or immediately in the case of a recurrent episode. The following cystitis symptoms were recorded at each time point: pain in the bladder, burning and stinging during urination, urinary urgency and frequent urination in small amounts. The criteria for defining a recurrent episode of cystitis were rebound lower urinary tract infection symptoms with pyuria and positive bacteriological urine culture. Results: Canephron®N in addition to fluoroquinolones helps to reduce cystitis symptoms after 7 days better compared to treatment with fluoroquinolones only, as well as pyuria after 3, 6 and 12 months and urine levels of E. coli at 3 and 12 months. The frequency rate of recurrent episodes of cystitis was in the test group always lower than in the control group with a statistically significant difference at 6 months (8.9% vs. 17.8%) and at 12 months (15.5% vs. 35.5%). At 12 months, the mean score of the LUTI Symptom Severity Index was 6 (p ≤ 0.05) in the control patients and 3 (p ≤ 0.05) in the test patients. This may indicate that the relapses were less severe in the test group. Conclusion: Treatment with the herbal medicine Canephron®N is a novel treatment method of alleviating the symptoms of cystitis and especially for reducing the rate of recurrent cystitis episodes.

The frequency of recurrence of urolithiasis within the first 3 years after treatment reaches 53%, of which more than half of cases are detected in the first year of follow-up. In the remote period of observation, the frequency of recurrent stone formation reaches 77%.The objective: to evaluate the metaphylactic effect of phytotherapy in patients with oxalate urolithiasis after extracorporeal shock wave lithotripsy (ESWL) of the ureteral calculi.Materials and methods. The clinical study was conducted as a non-interventional open controlled, in two groups of patients with initial state control. The study included 64 patients with urolithiasis, oxalate concreting ureter, who performed one session of ESWL and achieved complete fragmentation of the stone. All patients of the main group (n = 32) were prescribed basic therapy + herbal medicine for 1 month with a repeat treatment at 6 months. Patients of the control group (n = 32) received baseline therapy without the study drug. The duration of follow-up is 12 months.Results. After 12 months of observation in the patients of the main group, the concentration of citrates in the urine was 2.67 ± 0.14 mmol / L compared with 2.32 ± 0.11 mmol / L in the control group (p <0.05). In patients of the main group, the daily excretion of oxalates after 12 months of observation was reduced to 38.4 ± 3.45 mg / d compared with the control group patients - 50.1 ± 2.56 mg / d (p <0.05). After 12 months of observation, a consistently high diuresis was noted in the patients of the main group 1.96 ± 0.24 l / d compared with patients of the control group 1.62 ± 0.12 l / d (p <0.05). The concentration of uric acid in the urine of the patients of the main group decreased to 4.42 ± 0.27 mmol / L, in patients of the control group - up to 4.59 ± 0.22 mmol / l. After 12 months of observation, the serum uric acid concentration was 0.210 ± 0.64 ?mol / l in patients of the main group and 0.305 ± 0.73 ?mol / l in the control group (p <0.05).Conclusion. Results of examination after 12 months of metaphylactic treatment of patients of the main group with oxalate nephrolithiasis showed no recurrent stone formation, in the control group 3 (9.4%) of the patient with recurrent formation of concrements up to 5 mm in the pulmonary calcification system of the kidney (p <0.05 ). The obtained results confirm the pathogenetic mechanisms of the action of phytopreparation Urolesan® on risk factors for oxalate nephrolithiasis, which is manifested in the stable normalization of the risk factors of this pathology

Цель исследования: изучение действия препарата растительного происхождения Канефрон ® Н, в частности его эффективности при профилактике рецидивов цистита, вызванного E. сoli, у женщин детородного возраста. Методы. Девяносто пациенток были рандомизированы на две терапевтические группы. Пациентки обеих групп, исследуе� мой (n=45) и контрольной (n=45), в течение 7 дней получали антибактериальную терапию (фторхинолонами) по результа� там посева мочи. Кроме того, пациенткам обеих групп были даны общие рекомендации по профилактике цистита (употреб� лять достаточное количество жидкости, не допускать переохлаждения и т. д.). Пациентки исследуемой группы дополнитель� но принимали Канефрон ® Н в течение 3 месяцев (2 таблетки три раза в день). Контрольные обследования проводили на 7�й день, а также через 3, 6 и 12 месяцев; при возникновении рецидивного эпизода обсле� дование проводили безотлагательно. В каждый контрольный момент времени регистрировали следующие симптомы цистита: боль в мочевом пузыре, жжение и острую боль при мочеиспускании, неотложные позывы к мочеиспусканию и учащенное мочеиспускание маленькими порциями. Критериями установления рецидивного эпизода цистита были повторяющиеся симптомы инфекции нижних мочевыводящих путей, сопровождающиеся пиурией и положительным результатом бактериологического посева мочи. Результаты. По сравнению с монотерапией фторхинолонами применение Канефрона Н в сочетании с фторхинолонами эффектив� нее уменьшает симптомы цистита через 7 дней, а также пиурию через 3, 6 и 12 месяцев и уровень E. coli в моче через 3 и 12 месяцев. Во все контрольные моменты времени частота рецидивных эпизодов в исследуемой группе была ниже, чем в контрольной, при этом разница была статистически значимой через 6 месяцев (8,9% по сравнению с 17,8%) и через 12 месяцев (15,5% по срав� нению с 35,5%). Через 12 месяцев средний показатель тяжести симптомов инфекции нижних мочевыводящих путей (ИНМП) составлял 6 баллов (p≤0,05) в контрольной группе и 3 балла (p≤0,05) в исследуемой группе. Это свидетельствует о том, что в исследуемой группе рецидивы отличались меньшей тяжестью. Заключение. Применение лекарственного препарата растительного происхождения Канефрон ® Н представляет собой инновацион� ный терапевтический метод облегчения симптомов цистита и, в частности, снижения частоты рецидивных эпизодов цистита. Ключевые слова: лекарственный препарат растительного происхождения, цистит, пиурия, Канефрон ® Н. Canephron ® N in the Treatment of Recurrent Cystitis in Women of Childbearing Age: a Randomized Controlled Trial M.Ye. Sabadash, A.V Shulyak The objecrive: to study the effect of the herbal preparation Canephron ® N, in particular its effectiveness in the prevention of recurrence of cys� titis caused by E. coli in women of childbearing age. Materials and methods. Ninety patients were randomized into two treatment groups. Patients of both groups, study (n = 45) and control (n = 45), received antibiotic therapy (fluoroquinolones) for 7 days according to the results of urine culture. In addition, the patients of both...

triglycerides by 0.10 (À0.17;À0.043) mmol.L-1 whereas body mass index, total cholesterol, HDL-cholesterol, LDL-cholesterol and fasting glucose remained statistically unaltered (P > 0.05). Conclusions:The meta-analysis suggests that dynamic resistance training may reduce BP and favourably affect some other CV risk factors. However, additional studies are needed especially in the hypertensive populations.

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