Relevance. Unreasonably high pollutant emissions into the environment, the ill-considered use of natural resources and the raw material orientation of exports have led to an environmental crisis in many areas.Purpose. To study the effect of ecotoxicants on the histochemical structure of tooth and jaw germs in laboratory rats and ways to reduce this effect during perinatal prevention.Materials and methods. The experiment included 50 white outbred rats weighing 180-250 grams. All animals formed five groups: 1 control and four experimental. All animals of the experimental groups were subject to gasoline and formaldehyde vapours inhalation exposure; Group 1 (control) was subject to only poisoning with ecotoxicants, Group 2 had peptinsorbent associated with ecotoxicant poisoning, Group 3 – a membrane protector – magnolia vine, Group 4 – beet, Group 5 – peptinsorbent, membrane protector and beet.Results. The histochemical study of tissues around the tooth germs in pup rats born from the control group rats after poisoning with ecotoxicants revealed an increased mast cell number in the tissues compared to intact rats. The samples of Group 2 rats showed that the mast cell number and characteristics practically did not differ from the control group after ecotoxicant poisoning. In the rats of Group 3, the number of mast cells was slightly lower than in the control group. In Group 4, the number of mast cells was not significantly lower than in the control group. In the rats of Group 5, the number of mast cells significantly decreased compared to the control and other experimental groups.Conclusion. Thus, during subchronic poisoning of pregnant female rats with ecotoxicants, the number of mast cells in the gingiva of rat pups increases against the background of microcirculation disorders. The number of mast cells in gingiva significantly decreases and approaches the normal values in rat pups after feeding pregnant rats with the combined mixture (peptinsorbent+membrane protector Schisandra+beetroot).

The relevance of this work is related to solving the problem of soil pollution with heavy metals by applying Fallopia Sachalinensis and obtaining benefits in the recovery process. The aim of the work is to develop an algorithm for geoecological assessment of phytoremediation features when using plants, taking into account the conditions of anthropogenic soil pollution with heavy metals, as well as physiological characteristics and species-specific reactions under abiotic and biotic stress. For the quantitative determination of flavonoids in Fallopia Sachalinensis, a spectrophotometric method was used in the work on a Shimadzu – UV 1800 instrument using a complexing additive – 5% aluminum chloride solution, to determine the content of tannins, the redox titration method was used, in order to detect amino acids, qualitative reactions were carried out with aqueous extraction for three copies of each sample. Quantitative determination of amino acids in the studied samples is carried out on the AAA-339 amino acid analyzer (Czechoslovakia). Approbation of the algorithm on Fallopia Sachalinensis under conditions of anthropogenic contamination of soils of the Bashkir Trans-Urals with heavy metals showed that the plant has an indicator potential, but excludes the production of natural biologically active substances from biomass. At the same time, Fallopia Sachalinensis is resistant to soil pollution with heavy metals and has an increased resistance to industrial pollution, and the possibility of using it as an indicator of soil pollution has also been determined

Now in medical community are even more often discussed such concept as the complementary medicine (CM) and its integration into conventional medicine. One of the most widespread directions of CM is phytotherapy which is regulated by allowing documentation of bodies of health care and consequently it is included in conventional medicine. A serious problem of world health care is the diabetes mellitus. According to data of the International Diabetes Federation (IDF) for 2015, in the world there are 415 million people have the diagnosis a diabetes mellitus and by 2040 increase in number of patients up to 642 million. In Russian Federation 12,1 million people are sick a diabetes mellitus. For prophylaxis and at early stages of development of a diabetes mellitus of the 2nd type phytotherapy is recommended. Now there is the active searching of plants with hypoglycemic activity. The pharmacological effect of plants is caused by the biologically the active materials (BAM) which are their part which are very various on structure and, respectively, on the effect which had by them. The review of results of the researches confirming presence of hypoglycemic activity at the BAМ, most widespread in flora is provided in article (phenolic substances, polysaccharides, alkaloids, etc.), mechanisms of their action are described. The submitted data demonstrate that from a position of evidential medicine searching and development of the new means of a phytogenesis allowing to expand the range of the medicines applied at a diabetes mellitus are expedient. At the same time the greatest effect of phytotherapy can be reached when using the multicomponent herbal teas containing a larger range of BAM in comparison with individual plants that will allow to influence pathogenetic processes of a disease.

The article presents research of the chemical composition of lipophilic fractions of shoots Crataegus sanguinea Pall. (Rosaceae), Crataegus submollis Sarg. (Rosaceae) and Crataegus almaatensis Pojark. (Rosaceae). Lipophilic extract is obtained  from petroleum ether. The components of the lipophilic fraction were separated and identified by gas chromatography with mass spectrometry. 36 compounds were identified in lipophilic fractions: hydrocarbons, fatty acids, sugars, phenolic compounds, diterpenoids and sterols. Their presence may determine the pharmacological properties of hawthorn shoots. These research expand information about the chemical composition of these hawthorn species and can be used in the development of a new drug.