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Peptide immunocortin sequence corresponds to the amino acid residues 11–20 of the variable part of human immunoglobulin G1 (IgG1) heavy chain. Since immunocortin was shown previously to inhibit phagocytosis in peritoneal macrophages and ConA-induced T-lymphocytes proliferation in culture, we suggested that immunocortin administering may be of use for patients with self-immune syndrome. Immunocortin in concentration 10 μM inhibited proliferation of both antigen (myelin)-induced and ConA-induced LN lymphocytes isolated from the lymph nodes of Dark Agouti (DA) rats immunized with chorda shear. The biological trials of the synthetic immunocortin were carried out on the DA rats with induced experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. These in vivo experiments have shown that intraperitoneal injections of immunocortin in a daily dosage 100 μg per animal reduced symptoms of EAE in DA rats.

Immunosuppressant peptide immunocortin for the first time was described in 1993. It corresponds to residues 11–20 of human Ig heavy chain (conserved motif of VH domain). There are no data about production of immunocortin by proteolysis of Ig in vivo. Synthetic immunocortin in concentration ~ 10−9 M suppresses phagocytosis in peritoneal macrophages, ConA-dependent blast transformation of rat lymphocytes, exhibits ACTH-like neurotropic activity and was suggested as a potential drug for treatment of a multiple sclerosis (MS). Here, we report a sequence and method of synthesis of Abu-TGIRIS-Abu-NH2 (Abu, alpha-aminobutyric acid), an artificial analogue of immunocortin. Biological trials of peritoneally injected Abu-TGIRIS-Abu-NH2 gave an evidence of its better efficacy versus immunocortin in a test for suppression of the experimental autoimmune encephalomyelitis (EAE) in Dark Agouti (DA) rats.

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The article is devoted to the analysis of the linguistic and cultural type “Russian bureaucrat”. The compatibility of the adjective bureaucratic is investigated according to the texts of the XIX - XXI centuries included in the National corpus of the Russian language. The novelty of the study is that to describe the character traits of the linguocultural type “Russian bureaucrat”, the authors refer to the compatibility of an adjective derived from the character type. It is noted that the connotative component in the meaning of the adjective determines an almost exclusively negative interpretation of the image: the pejorative component of the value determines the compatibility of the studied adjective with the designations of negative qualities. The authors dwell on the ideas that have developed in the Russian linguistic consciousness about the character of the Russian bureaucrat, and trace their transformations over two centuries. The analysis of the compatibility of the adjective showed that the linguistic and cultural character “Russian bureaucrat” is characterized by indifference, ignorance, cowardice, arrogance, insincerity. The authors of the article conclude that in the Russian language picture of the world indifference and cowardice are attributed to bureaucrats of different periods of Russian history, while ostentatious arrogance is noted mainly in the descriptions of officials of the past, and markers of ignorance and insincerity are more frequent in the characteristics of modern officials.