Introduction. Medical imaging techniques can diagnose many diseases at the early stages of their development, improving the patient survival. Artificial intelligence (AI) systems, requiring the high-quality annotated and marked-up sets of medical images, are a suitable and promising means of improving the diagnostics’ quality. The purpose of the study was to develop a methodology and software for creating AIS training sets. Material and methods. We compared the main annotation methods’ performance and accuracy and based the information system on the most efficient method in both domains to develop an optimal approach. To markup objects of interest, we used the cluster model of lesions localization previously developed by the authors. We used C++ and Kotlin programming languages for software development. Results. A structured annotation template with delivered a glossary of terms became the basis of the information system. The latter consists of three interacting modules, two of which are executed on a remote server’s capacities and one on a personal computer or mobile device of the end-user. The first module is a web service responsible for the workflow logic. The second module, a web server, is responsible for interacting with client applications. Its role is to identify users and manage the database and Picture Archiving and Communication System (PACS) connections. The front-end module is a web application with a graphical interface that assists the end-user in images’ markup and annotation. Conclusions. An algorithmic basis and a software package have been created for annotation and markup of CT images. The resulting information system was used in a large-scale lung cancer screening project for the creation of medical imaging datasets.

The purpose of the work is to study the features of the body mass index (BMI) in schizophrenia patients (SP) who live in Chuvashia. Material and methods. 607 SP were examined (307 men and 300 women) aged 18 to 82 (average - 44.51 ± 12.3 years). The diagnosis of schizophrenia met the criteria for ICD-10 (F20-29); disease duration ranged from 0 to 52 years (mean - 18.9 ± 10.7 years). BMI was taken into account according to the Ketle index. For each SP, a survey card with clinical, therapeutic, and socio-demographic indices was filled out. The comparison group included a sample of 3417 residents of Chuvashia. Mathematical and statistical processing was carried out using descriptive statistics and χ2 distribution. Results. 9.2% of SP had underweight, 54.2% - normal body weight, 36.6% - excess body weight and obesity. Among women there were significantly more persons with increased BMI and obesity, among men - with normal BMI. In SP, BMI did not depend on the group of taken antipsychotics (typical, atypical, mixed-use) and the disease’s duration. With patients’ age, BMI increased to excess BMI (25-29.9 kg/m2). Among SP, persons with underweight were much more common (among healthy people, 2% vs 9.2% in SP). From 40 years of age and older, among the healthy population, persons with an increased BMI and obesity begin to predominate significantly compared with the SP group. Observations of BMI during inpatient treatment from 1.5 to 22 months showed multidirectional dynamics, including increased body weight in 42.2% of SP, a decrease in 30.1%, without changes in BMI in 27.7%; it was not possible to retrospectively identify any patterns of BMI fluctuations. Conclusion. The revealed paradoxes of BMI for SP in Chuvashia, especially a high proportion of SP with underweight, require refinement considering ethnic, genetic, sex and age, hormon and metabolic factors.

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The purpose of the research is to provide a comprehensive analysis of approaches to the organization of events for the implementation of Moscow’s development programs, from the point of view of strengthening public health. Materials and methods. The methods of the study are: the integrated assessment of data of industry statistical reporting, the method of descriptive statistics, the method of content analysis. Approaches to the organization of events of the state programs of the city of Moscow, from the point of view of strengthening public health, are defined. It is shown that the state programs include areas related to strengthening public health, their implementation is carried out jointly by various departments and is of an interdepartmental nature. Urban planning policy and development of the territories of the city of Moscow is carried out in accordance with the analysis of the environmental situation, demography, and social needs of citizens. Correlation between the state of public health in Moscow according to the results of clinical examination and ongoing activities of state programs of Moscow, shows the relevance of interagency measures to enhance public health and promote a healthy lifestyle. Results. The results of medical examinations in 2017−2019 show that it is necessary to strengthen interdepartmental measures aimed at strengthening public health in the city of Moscow.

The global trend is currently an increase in mortality from noncommunicable diseases (NCD): cancer, cardiovascular, endocrinological, respiratory diseases. The COVID-19 pandemic has not stop the NCD epidemic, and gender characteristics, syndemicity, and polymorbidity of them contributed to persistence of differences in the number of years of life lost due to premature mortality among men and women (calculations for 2019 using the DALY method without taking into account the impact of health deterioration due to disability). The main losses from NCD-related premature mortality are connected with neoplasms and diseases of the circulatory system, that is fundamentally consistent with the general trend of age-related health deterioration, although at the age of the first five years of the «new retirement age» (65-69 years), there is a «gender reversal» of premature mortality: its share decreases in men, and increases in women. The age dynamics of changes in the number of deaths from neoplasms shows two peaks, one of which is particularly alarming — in children and adolescents, the proportion of deaths from it exceeds the corresponding indicator for cardiovascular and respiratory diseases, thus indicating cancer risk to children's health. In Russia, since May2020, excess mortality of the population has been recorded, 40% of which fell on NCD, and 60% — infectious diseases, including COVID-19 as the main or worsening cause of death from the underlying disease. The anti-epidemic reorientation of national health systems has had a significant negative impact on the health of patients with NCD, requiring special measures. At the same time, there is a favorable moment for a breakthrough development of the telemedicine services market, although it is constrained by the current legislation that prohibits establishing diagnosis and prescribing treatment during remote consultations.