The effect of the probiotic preparation Vetom 1.2 on the basis of Bacillus subtilis VKPM B-10641, Bacillus amyloliquefaciens VKPM B-10642 and Bacillus amyloliquefaciens VKPM B-10643 in different doses on the correlation interactions between the parameters of turkey hemoglobin exchange, blood erythrocytes and blood red blood cells direct and total bilirubin, total protein and serum albumin was studies. Correlations were calculated using Spearman formula, the reliability of correlations was checked by Student. The formulation was used for turkeys once a day for 30 days in doses of 12.5; 25; fifty; 75 and 100 mg / kg body weight. It was found that Vetom 1.2 in minimal doses leads to an inverse correlation between iron and total bilirubin, direct bilirubin, total protein and albumin, an increase in the concentration of the formulation leads to the disappearance of this effect with a gradual subsequent decrease in this indicator. Vetom 1.2 in doses up to 50 mg / kg leads to an inverse correlation between the concentrations of hemoglobin and direct bilirubin, total protein and serum albumin, at a dose of 75 mg / kg there is a direct correlation between these indicators, and at a dose of 100 mg / kg returns a negative correlation. The probiotic preparation Vetom 1.2 leads to a direct dependence of the concentration of bilirubins (total and direct) in serum on the concentrations of hemoglobin and red blood cells when used in most doses, except 75 mg / kg, which reduces the correlation.

Purpose: To determine computed tomography subtypes of amiodarone-induced pulmonary toxicity (AIPT). Material and methods: We included 214 CT exams of 110 patients with history of amiodarone use. AIPT was confirmed in 90 cases. In 81 % of patients we repeat CT exam 2–5 times, observation period till 1 month to 10 years. The mean age of patients was 71 years (21 females, 69 – males). In 52 % of patients lung scintigraphy was done. We included functional lung test, spirometry, heart ultrasound in diagnostic plan. Results: Only in 3 % of cases we detected acute form of AIPT. In 68 % of patients subacute form was revealed, in that cases we indentified different patterns of lung defeat, which mimic oncology disease, different types of interstitial pneumonias, small vessel pulmonary embolism. In other cases chronic form AIPT was suspected. Unilateral changes and craniocaudal gradient were not pathognomic for AIPT. We did not identify consolidation zones and nodules. Honeycombing was not a typical feature of chronic form of AIPT. Appearance of ground-glass opacity pattern was feature of lung toxicity exaxerbation. Conclusion: AIPT diagnose of exclusion because of it’s multiple radiological subtypes. There are no specific histological or cytological markers of the disease. Only CT could identify signs of active process and differentiate different subtypes of AIPT.

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The effect of the drug Fungin Forte in combination with the probiotic drug Vetom 1 was studied in the complex therapy of feline microsporia. 2 groups of 5 cats each with a diagnosis of microsporia and the same initial size of alopecia were formed. Cats of the control and experimental groups were given a combined antifungal drug Fungin Forte, applying it for 21 days in a thin layer on the affected areas 2 times a day, rubbing from the periphery to the center. The experimental group cats were additionally given the probiotic preparation Vetom 1 inside at a dose of 50 mg / kg for 20 consecutive days. The therapeutic efficacy of the treatment of feline microsporia was assessed by reducing the severity of clinical signs of dermatomycosis by measuring alopecia and plotting changes in their size. Blood sampling was performed from the anterior saphenous vein of the forearm before and after therapy. The concentration of erythrocytes and hemoglobin was measured on a Mindray BC-2800 automatic hematology analyzer. It was found that Vetom 1 increases the concentration of hemoglobin in the blood and the number of erythrocytes within the physiological norm, which helps to improve the general condition of animals during therapy with Fungin Forte. When using Vetom 1 against the background of using the drug Fungin Forte, the resistance of the organism of animals of the experimental group increases, the process of restoring the skin barrier and reducing alopecia on the coat is accelerated, which is directly proportional to the decrease in the amount of the pathogen on the skin.

Community-acquired pneumonia (CAP) in patients with interstitial lung diseases is a terrible complication and has an atypical course. Diagnosis of CAP is difficult, since the clinical symptoms of inflammation are similar to those of ILD. The results of radiation studies are not pathognomonic, they are not always correctly interpreted, which leads to errors in diagnosis, delay in the examination and treatment of the patient. Aims: to evaluate the possibilities of CT in the detection and differential diagnosis of pneumonia in patients with ILD. Material and methods. The results of a complex clinical and radiological studies of 336 patients with IZL, 48 patients showed infiltrative changes in the lungs that were not characteristic of the main process. Results. Nonspecific inflammatory changes in the lung tissue were manifested by the following CT symptoms: alveolar type with local infiltration of the lung tissue corresponding to the segmental structure of the lungs (segment, lobe), the appearance of peribronchial alveolar type lung tissue that is not characteristic of radiation semiotics of the underlying disease. Conclusions: рerforming CT and VRKT reveals the appearance of infiltrative and focal changes that are atypical for IL, characteristic of specific and non-specific inflammatory processes, which affects the treatment tactics of patients.