1Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow; 2A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow; 3Kazan State Medical University, Kazan; 4Kazan (Volga) Federal University, Kazan; 5Far Eastern State Medical University, Ministry of Health of Russia, Khabarovsk; 6Morozov City Children’s Clinical Hospital, Moscow Healthcare Department, Moscow; 7I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint Petersburg; 8Siberian State Medical University, Ministry of Health of Russia, Tomsk; 9M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow; 10Maimonides State Classical Academy, Moscow; 11V.I. Razumovsky Saratov State Medical University, Saratov; 12I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow; 13S.M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, Saint Petersburg; 14Surgut State Medical University, Ministry of Health of Russia, Surgut; 15City Clinical Hospital Five, Moscow Healthcare Department, Moscow; 16Nizhny Novgorod Medical Academy, Ministry of Health of Russia, Nizhny Novgorod; 17Territorial Clinical Hospital Two, Ministry of Health of the Krasnodar Territory, Krasnodar; 18Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia, Saint Petersburg; 19Rostov State Medical University, Ministry of Health of Russia, Rostov-on-Don; 20Omsk Medical University, Ministry of Health of Russia, Omsk; 21Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia, Moscow; 22Novosibirsk State Medical University, Novosibirsk; 23Stavropol State Medical University, Ministry of Health of Russia, Stavropol; 24Kemerovo State Medical University, Ministry of Health of Russia, Kemerovo; 25N.I. Pirogov Russian Research Medical University, Ministry of Health of Russia, Moscow; 26A.M. Nikiforov All-Russian Center of Emergency and Radiation Medicine, Ministry of Emergency Situations of Russia, Saint Petersburg; 27Federal Research Center, Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Research Institute of Medical Problems of the North, Krasnoyarsk; 28S.P. Botkin City Clinical Hospital, Moscow Healthcare Department, Moscow; 29Tver State Medical University, Ministry of Health of Russia, Tver The Russian consensus (a consensus document) on the diagnosis and treatment of chronic pancreatitis has been prepared on the initiative of the Russian «Pancreatic Club» under the Delphi system. Its aim was to identify and consolidate the opinions of Russian experts on the most topical issues of the diagnosis and treatment of chronic pancreatitis. The interdisciplinary approach involved the participation of leading gastroenterologists, surgeons, and pediatricians.

Introduction: Early detection of PC is the main clue for improving results of treatment. Liquid biopsy (LqB) is the most promising method of detection of disease in a screening context, but selection of biologic material for that is not a resolved problem. Pancreatic juice is the highly specific substance for that aim. However, its collection and analysis are associated with many technical difficulties. Materials and Methods: For pancreatic juice collection we developed a method of ALB using a proprietory pancreatodigestive stent. This stent allows for active aspiration of pancreatic juice. We had recruited 15 patients with verified PC before treatment. Placement of the stent was performed by endoscopy and followed by collecting of pancreatic juice in sterile container at 4o C. After collecting sufficiently large volume of the material, we centrifugated it and made cell-block for cytologic examination. Results: ALB was performed in all 15 cases without any complications. Placement and removal of the stent was atraumatic and without technical problems. However, only in 1 sample out of 15 did we detect atypical cells using standard cytologic examination. Conclusion: We present new methodology for collecting biomaterial potentially useful for the early diagnosis of pancreatic cancer. This method is simple and can be easily replicated. Its application does not require high-quality specialized medical centers and personnel and can be performed in standard gastroenterologic clinics. Collected samples can be easily stored. Furthermore, in addition to cells it allows to obtain the liquid fraction of pancreatic juice that could be used for the detection of tumor DNA. Citation Format: Aleksei Kashintsev, Nikolai Kokhanenko, Evgeniy Imyanitov, Vitaliy Proutski, Oleg Granstrem, Lyudmila Solovieva, Konstantin Medvedev, Konstantin Pavelets, Sergey Anisimov. Aspiration liquid biopsy (ALB) of pancreatic cancer (PC) [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; 2019 Sept 6-9; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2019;79(24 Suppl):Abstract nr C25.

ТОМ 5Н а ш а и с т о р и я Вклад легендарного хирурга и онколога Макса Вильмса в клиническую медицину (к 150-летию со дня рождения)

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