No abstract

The One Health movement aims to provide integrated responses to problems that emerge at the intersections of human, animal, and ecological health. However, it risks derailment due to over-reliance on top-down global responses and generalisations that often fail to fit real-world settings. In this article, we examine the case of parasitic Opisthorchis felineus infection in Western Siberia and argue that understanding the local social dynamics of disease exposure and transmission, and how people live their lives in interactions with other species is crucial for making One Health work in practice. This qualitative study was conducted in preparation for developing an opisthorchiasis control programme and involved 20 in-depth interviews, participant observation, and multiple unstructured interviews in the village of Melnikovo. We explored the social dynamics of O. felineus transmission and designed a participatory model of these dynamics. This model attests to the specificity of transmission dynamics in Western Siberia and demonstrates the importance of understanding this public health issue as embedded in social networks and animated by a variety of locally-specific linkages between ways of life, food and health cultures, health-care systems, economies, and landscapes. Our work highlights that such participatory approaches have to be an integral part of One Health interventions if these interventions are to be effective and legitimate.

This publication is devoted to the analysis of the amendments to the Federal Law “On Compulsory Health Insurance in the Russian Federation” of 29.11.2010 No. 326-FZ, which entered into force on 01.01.2021, as well as other related regulatory legal acts. The purpose of the work is to analyze the reasons that led to the need to improve the regulatory framework for mandatory health insurance; the content of the main changes in federal legislation and other regulatory legal acts regulating the field of mandatory health insurance, as well as to assess the consequences of these changes.

In the present research the complex cytologic and biochemical estimation of a condition induced sputum at 19 patients with the heavy therapeutic-sensitive form of a bronchial asthma and 18 patients with chronic obstructive disease of lungs is lead. Dominating morphological and biochemical markers of an asthma became the raised number of macrophages, lymphocytes, and eosinophils at decrease in functional activity neutrophil elastase and increases activation properties. Progressing of destructive and fibrous processes at patients with heavy form chronic obstructive pulmonary disease occurs on a background active neutrophil and lymphocytes reactions in a mucous membrane of bronchial tubes that proves to be true high activity elastase and falling of functioning proteinase inhibitor.

Background. The technological direction digital Twins is included in the list of the main strategic technological trends of 20192021. At the end of 2021, an initiative was announced in the Russian Federation aimed at creating a digital twin in the domestic healthcare system as part of the primary care modernization project. Aims the purpose of the study is to review possible ways of using digital twins technology in the global healthcare system and in its Russian segment, as well as to build patent and publication landscapes to identify technological and academic leaders of the frontier. Methods. Scientometric and patent analysis. Results. The key stages of the development of the frontier digital twins in healthcare are traced. According to the data of the scientometric and patent analyses carried out in the priority direction digital twins in healthcare and medicine, the Russian Federation at the end of 2021 ranks 35th in the world in terms of specific weight in the total number of articles in publications indexed in WoS, and 20th in the world in terms of specific weight in the total number of patent applications for an invention, i.e. it is not among the 10 leading countries. The citation of domestic publications in the internationalized segment is significantly lower than the average (normalized) indicator, which does not give grounds to talk about the achievement of research excellence and even world-class domestic competence centers. Conclusion. The creation of the Digital Healthcare Consortium in 2018, the world-class Scientific Center Digital Biodesign and Personalized Healthcare in 2020 and the initiative of the regulator (Ministry of Health of Russia) in 2021 should be noted as key events in the development of the frontier in the Russian Federation. At the same time, it is important to note that the main global actors in the transformation of the digital twins frontier into high-tech equipment and services are not research centers, but companies acting simultaneously as qualified customers and beneficiaries of ongoing projects of a full innovation cycle. Having huge RD budgets and having a clear goal setting, it is these participants in the process that become the main drivers of the technological development of the healthcare sector associated with the introduction of digital twins. In this regard, the absence of the direction of Russian companies on the patent landscape cannot but cause concern, which creates risks of using innovative solutions created in the domestic sector of interdisciplinary research in the interests of foreign corporations identified as technology leaders in this review.