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The study of the immune status markers and characteristics of genetic polymorphism in potash mining workers under the impact of combined industrial factors was performed. We showed the inhibition ofphagocytosis and production of serum IgG and IgM, the deficiency of mediators of the immune and endothelial regulation of interleukin-17, VEGF, GAD1 and GAS6. The revealed changes are associated with the negative genetic fixation of key polymorphisms responsible as well for the detoxification of the first and second phase of the neuro-immune regulation, the state of the vascular endothelium and apoptosis, as both due to heterozygous and due to the homozygous variant genotypes of genes of cytochrome (CYP1A1), Sulfotransferase (SULT1A1), toll-like receptor (TLR4), tumor necrosis factor (TNF), endothelial growth factor (VEGFA)

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We conducted the comparative assessment of the results of immune diagnostics and analysis of polymorphism of genes in children exposed to the aero-technogenic contaminants with the genotypes of their parents. We established the genetic polymorphism of detoxication genes CYP1A1, CPOX, SULT1A1 as well as the alternative allelism of genes characterizing the condition of the endothelium of vessels (VEGF and eNOS) both for children and their parents. The presented data evidence the genetic fixation of minor genotypes of parents in children exposed to the chemical risk factors.