In numerous researches there is the confirmation of multidirectional changes of the morphological and functional parameters of jejunum mucous membrane at influence of the electromagnetic fields, which manifest by reactive processes and adaptation reactions depending on parameters of influencing sources of radiation: the impulses frequency, intensity and the influence duration. Their combination reveals various consequences of irradiated biological object. The experiment was made on white non-pedigree mail rats, with initial age 4 month, after 10-month’s exposure of the electromagnetic factor. The density of the directed currents in body of the experimental animals has compounded 0,8, 2,7 kA/m2 50, 100, 500 impulses per one week (i/w), independently of their divisibility on days and duration 15-40 ns. The comprehensive analysis of correlation of epitelio-connective-tissue interactions of mucosa jejunum allows to establish the morphological and functional interrelations between them, as the unified system which taking part in regulation of a fibrohomeostasis and reactions of adaptation in the conditions of electromagnetic radiation. The results of the analysis lead to the conclusion that participation of fat cells in the modification of bioeffective and EMF in relation to the processes of renewal of the villi epithelium.