In the scientific and economic research we investigated the influence different levels of mixed ligand complex of Cobalt on milk productivity and its exchange in the organism of highly productive cows of Ukrainian Black-and-White milk breed in combination with sulfates: Zinc 650 g/t, potassium 38 g/t, sodium selenite 1.8 g/t. For cows of the 1st control group, we administrated 8.9 g/t of cobalt sulfate, 2nd group -9.7 g/t of mixed ligand complex of cobalt, 3rd, 4th and 5th experimental groups respectively, were fed into rations, g/t: 7.3; 4.9, and 2.4. As a result, the cows of the 1st control group and the 2nd experimental group the deficit in Cobalt was eliminated 100 % to the current norm, and for cows of the 3rd, 4th and 5th experimental groups -75, 50 and 25 %. The conducted researches have proved that the highest average daily milk yield of natural fat had cows of the 3rd experimental group, which consumed mixed fodder in the composition of mixed ligand complex of Cobalt in the amount of 75 % by concentration of the metal, which prevailed the analogues of the control group for this indicator, respectively, by 4.4 kg (р≤0.01), or by 9.7%. Cows of the 2nd, 4th and 5th experimental groups according to the average daily milk fat content of the natural fat were dominated by analogues of control, respectively, by 2.1 kg or 4.8 %; 3.2 kg or 7.1% (p≤0.05); and 1.3 kg, or 2.9 %. During the experiment, fat content of milk of cows of the 3rd experimental group exceeded fat content of milk of control group of cows by 0.03%, and in terms of milk, the 4% fat content milk yield was 3649.7 kg, which is 10.8 % (p≤0.01) higher yields of experimental cows in the control group. As for the content of protein in milk, there was no significant difference between the groups in this indicator. The use of sulfuric acid Cobalt in accordance with the recommended norm in the diet of experimental cows resulted in its positive balance in the body at 4.87 mg per head per day. And in the cows of the 2-5th experimental groups who ate this trace in the form of a mixed ligand complex the balance was, respectively, 8.19 % (p≤0.01), 10.07 (p≤0.01), 8.89 (p≤0.01), and 8.05 (p≤0.01).

The influence of the main parameters on the process of obtaining artificial carnallite and its quality has been established. It is shown that to obtain a product with a high content of the carnallite phase and a low content of bischofite and KCl, it is necessary to use magnesium chloride solution with the concentration of 27-30 % and preheated ground potassium chloride. The process should be carried out at the temperature of 80 °C. The formation of synthetic carnallite, close in composition to the enriched one, occurs when the ratio of potassium chloride to magnesium chloride in the initial mixture is equal or close to their stoichiometric ratio in carnallite. With an excess of potassium chloride in the reaction mixture, an increased content of potassium and sodium chlorides in the product is observed, and with its deficiency, the product contains an increased amount of bischofite phase. To reduce the hydrolysis of magnesium chloride during dehydration, a slight excess of potassium chloride should be maintained in the mixture entering the synthesis. It is shown that the most advantageous scheme for producing artificial carnallite provides for incomplete evaporation of desulfurized liquor in the presence of potassium chloride with the return of circulating carnallite liquor to the desulfurization stage.

The aim of the work was to assess the possibility of the cytological method in the diagnosis of epithelial liver tumors and to determine the cytomorphological criteria in the differential diagnosis of liver carcinomas. The authors analyzed the data of 106 fine-needle aspiration biopsies and 167 smears-prints during cor-biopsy of masses of the liver in patients who were examined at the polyclinic of the oncological dispensary in Nizhny Novgorod in 2016. - 2017 As a result, full-fledged material for cytological examination in the form of smears-prints from cor-biopsy and fine-needle aspiration biopsies was obtained in 75.4% (n=126) and 95.2% (n=101), respectively. The great possibilities of the cytological method are shown: an affirmative diagnosis of the presence of primary or metastatic liver lesions was made in 88.8% (n=112) based on smears of sorbiopsy prints and in 87.1% (n = 88) with fine-needle aspiration biopsies. Typical cytomorphological criteria for primary and metastatic liver carcinomas made it possible to determine the origin of the primary tumor in 56.6% of cases (n=98).

Introduction. Squamous cell carcinoma is a rare form of breast cancer, makes up no more than 2% of invasive breast cancer, usually found in old age. The effectiveness of the cytological research method in the preoperative diagnosis of breast cancer directly depends on the sample preparation of the obtained material. Description of the clinical case. The possibilities of cytological diagnostics are presented using modern methods of sample preparation such as liquid cytology, cell blocks. Conclusion. Features of the cytological picture in combination with clinical and radiological data should become the basis for reliable diagnosis of squamous breast cancer at the preoperative stage.

Due to the fact that polyhalite ores are poorly soluble in water, it was of interest to study the method of their processing using acids. The influence of polyhalite size, the hydrochloric acid concentration and consumption, the ratio of L: S, the temperature and time of mixing the pulp on the useful components extraction into the solution have been studied. The optimal conditions for the decomposition of polyhalite with hydrochloric acid have been determined. The degree of useful components extraction into the solution depends on the concentration of hydrochloric acid or on the L:S ratio of the pulp, but in all cases the decomposition of polyhalite occurs without secondary crystal formation, as evidenced by the same degree of potassium and magnesium ions extraction. The degree of potassium and magnesium ions extraction from polyhalite into solution increases with decomposition process temperature, an increase in the consumption of acid and the duration of the reagents interaction, and decreases with increasing acid concentration. The CaSO4 content in the solution increases sharply with an increase in the HCl concentration and is practically independent of the process temperature. Hydrochloric acid extract can be used for phosphate raw decomposition in order to obtain complex fertilizers.