Introduction. The topic of telemedicine in Russia is now extremely relevant in connection with the current coronavirus infection in the pandemic. Diagnostics and prevention of the spread of epidemics, as well as remote treatment of patients, is currently the main task of the telemedicine section of the provision of cancer care in the Republic of Bashkortostan. The spread of the coronavirus infection COVID-19 has become a new challenge and a powerful impetus for the rapid development of telemedicine technologies (TMT) in the Republic. Materials and methods. The article describes in detail the algorithm for conducting telemedicine consultations (TMC) at the level  doctor-doctor  in the profile  oncology  upon requests from medical organizations of levels 1, 2, 3 received through the Republican Medical Information and Analytical System of the Republic of Bashkortostan. Results. The results of the work of the Republican clinical oncological dispensary (RСOD) telemedicine service for 2020 are presented. RСOD consultants conducted 32,295 telemedicine consultations on the  oncology  profile directed by medical organizations of the 2nd and 3rd levels of the Republic of Bashkortostan. With the introduction of TMK into the oncological service of the Republic of Bashkortostan, there was a natural shortening of the examination time for cancer patients. The remote appointment of the necessary examinations one day prior to a full-time visit to a specialized RKOD specialist made it possible to shorten the time frame from the time of establishing an oncological diagnosis to the oncological consultation and the beginning of specialized treatment. Conclusions. The widespread introduction of telemedicine in the work of the oncological service of the Republic of Bashkortostan may turn out to be a powerful tool for providing quality care while maintaining patient safety in a pandemic. The impact of the pandemic could turn teleoncology into the main practice of providing outpatient medical care for cancer patients.

Background. Our previous studies have shown that postnatally formed lymph nodes (PNFLN) can serve as a source of biological signals activating antitumour immune reactions and suppressing the spread of metastatic malignant cells.Aim. To determine the expression of CD3, CD20, CD68 in native, sentinel and postnatally induced lymph nodes of the axillary zone in breast cancer.Materials and methods. The study involved an analysis of digitalized images of the immunohistochemical expression of a fixed panel of antibodies CD3, CD20, CD68. The expression levels were assessed quantitatively by counting the expressed cells in each studied node for four main structural and functional zones.Results and Discussion. The results of a comparative immunohistochemical study of native, sentinel and postnatally induced lymph nodes showed that the content of CD3, CD20, CD68 demonstrates fundamental differences in different lymph node structures.Сonclusions 1. In postnatally induced lymph nodes, compared to native and sentinel lymph nodes, the distinct expression of antibodies to the main immunocompetent cells, which realize key immune responses in the lymph node, can indicate an increased functional status of the newly formed lymph nodes. 2. The study demonstrated a high level of antigenic stimulation of T and B lymphocytes in postnatally induced lymph nodes, as well as indicated a possible role of macrophage cells in the stimulation of neolymphogenesis and the formation of new lymph nodes. 3. The study provides the basis for further research into postnatal induced lymph nodes in cancer patients.

The issues of medical statistics on mortality from cancer, especially the correctness of such indicators, attract general interest. In a comparative aspect, mortality rates in different countries are given and the possible influence of various factors on the distortion of these indicators is described. The death rates in the Russian Federation, the Republic of Bashkortostan and Ufa are considered in detail. Comparison of the number of doctors and oncologists in the republics of Bashkortostan and Dagestan revealed some differences in the territories by the availability of doctors, especially oncologists. At the same time, the ratio of morbidity and mortality in these territories are in similar and correct parameters. A detailed analysis of the letters of the Ministry of Health of Russia with recommendations relating to the principles of coding for cancer in combination with another pathology. The statistical incident was the change in the coding rules for a post-mortem diagnosis in 2011 and the peculiarities of the translation of the text from ICD-10. According to the results of the analysis, proposals were developed aimed at the objectification of mortality rates and 5-year survival of cancer patients.

Introduction. Neuroendocrine breast tumors represent a rare subtype of breast cancer, accounting for less than 1 % of all neuroendocrine neoplasms. Starting from their pathology definition, and going through their prevalence, prognosis and treatment, our knowledge is still really uncertain.Materials and methods. The article presents a rare clinical observation of a neuroendocrine breast tumor. A breast fibroadenoma was diagnosed at the initial diagnosis stage in a private clinic; after a surgical treatment and further morphological study, it was estimated: a diagnosis of Cancer in situ of the left breast T1N0M0, stage I. Next, 3D-conformal remote radiation therapy was performed on the area of the left breast.Results and discussion. After conducting positron emission tomography, multiple metastases were detected in the lymph nodes, bones, and liver. Additionally, micropreparations were consulted at the Federal Reference Center in St. Petersburg and at an independent third-party molecular biological laboratory in Germany (Munich). Given all the instrumental, molecular biological, histological and immunohistochemical studies of the patient, an individual regimen of drug therapy was selected.Conclusion. After 18 months of personalized drug therapy, we observed a positive trend and a significant decrease in metabolic activity according to positron emission tomography.

This brief review is devoted to the role of tertiary lymphoid structures in oncological processes. A number of research studies carried out over the past ten years have shed light on the functions of such structures in various diseases, as well as their role in the progression of the pathological process or resolution of a disease. The data presented in some research works confirms the relationship between the presence of tumour-specific (tumour-associated) tertiary lymphoid structures and a favourable prognosis in patients with various oncological diseases, which suggests the participation of tertiary lymphoid structures in effective local antitumour immune responses. However, no reliable evidence has so far been obtained that could confirm the contribution of tertiary lymphoid structures to immune processes in vivo, with the available information being largely of a correlative character. It should be emphasized that the clinical significance of tertiary lymphoid structures ranges from a destructive to protective impact, which indicates the need for an improved understanding of the structure and case-specific function of these organs before conducting clinical targeting.