Peptic ulcer disease is a chronic disease of the gastrointestinal tract, mainly manifesting itself in the formation of the fairly persistent ulcer defect of the mucous membrane of the stomach and/or duodenum. Association analysis of common polymorphisms of matrix metalloproteinases genes MMP 1 (rs1799750, rs494379), MMP 2 (rs2285052), MMP 3 (rs3025058), MMP 9 (rs3918242, rs17576), and MMP 12 (rs2276109) and their tissue inhibitors TIMP 2 (rs8179090) and TIMP 3 (rs9619311) was carried out in 353 patients with a gastric ulcer or duodenal ulcer and in 325 unrelated healthy individuals from the Republic of Bashkortostan. Associations of polymorphic variants rs1799750 and rs494379 of gene MMP 1, rs3025058 of gene MMP 3, rs3918242 and rs17576 of gene MMP 9, and rs9619311 of gene TIMP 3 with the risk of peptic ulcer disease in Russians and Tatars were revealed.

Introduction.Acute appendicitis takes the first place in incidence among acute surgical disorders of the abdominal cavity organs. While many issues of the diagnosis and treatment strategy of this disease have been studied in detail, the diagnosis of acute appendicitis remains primarily a matter of clinical presentation. National guidelines on acute appendicitis also recommend additional methods for a number of stipulated situations; these methods include the Alvarado score. The key goal of this study is to analyse the results of using the Alvarado score in the diagnosis of acute appendicitis and juxtaposing these results with the laparoscopic and pathomorphological data.Materials and methods.This non-randomised prospective study presents the analysis of examination and treatment of 4,941 patients with acute appendicitis from the two periods — from 2006 to 2010 and from 2011 to 2015 — which is before and after the Alvarado score was introduced into the examination protocol. The likelihood of acute appendicitis according to the Alvarado score is evaluated as follows. A score of one to four is interpreted as appendicitis is unlikely; a score of five or six — acute appendicitis is possible, further dynamic observation is required; a score of seven to ten indicates a most probable acute appendicitis.Results and discussion.The total sensitivity of the scoring system exceeded 90%; however, it did not result in a reduction of the number of diagnostic laparoscopies.Conclusion. The authors see as the upsides of the use of the Alvarado score the improvement of the diagnostic precision and the reduced incidence of catarrhal appendicitis (down to 0.1%) and gangrenous forms of appendicitis (from 14.6% to 8.9%) due to a shorter observation period. The authors explain the failure to achieve the result planned by the healthcare funding costs and the drive to obtain a more precise diagnosis.

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Creative surgery and oncologyСreative surgery and oncology. 2017;7(3): нарушений органов брюшной полости, а также лактата как маркера ишемии проведено моделирование абдоминального компартмент-синдрома путем напряженного пневмоперитонеума под давлением 20 мм рт.ст. в течение двух часов на 5 свиньях массой 60-70 кг и на 7 поросятах массой 8-10 кг. Предложен алгоритм диагностики в до -и послеоперационном периодах.Результаты. Установлено, что современные лабораторные (уровень лактата) и инструментальные (эндоскопические, ультразвуковые, рентгеноконтрастные, лазерная флоуметрия и др.) методы позволяют с точностью >90% диагностировать ишемические нарушения кишечника.Заключение. Для контроля состояния кишечника и зоны анастомозов рекомендовано использовать методику программированной фибролапароскопии через контрольный дренаж брюшной полости.Ключевые слова: ишемия, реперфузионные повреждения, кишечная непроходимость, лабораторная диагностика, эндоскопия, ультрасонография, анастомоз хирургический

Simultaneous approach increases duration of surgery 30.3% on the average that is significant risk factor in case of surgery of severity degree III and videolaparoscopic interventions. Simultaneous surgery does not significantly increase ICU-stay and incidence of postoperative complications.